Steven Stellman - Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study

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      White, A. J., Teitelbaum, S. L., Stellman, S. D., Beyea, J.,   Steck, S. E., Mordukhovich, I., McCarty, K. M., Ahn, J., Rossner,   P., Jr., Santella, R. M., Gammon, M. D. 13 (1) 108-

      Abstract: BACKGROUND: Previous studies suggest   that polycyclic aromatic hydrocarbons (PAHs) may adversely affect   breast cancer risk. Indoor air pollution from use of indoor   stoves and/or fireplaces is an important source of ambient PAH   exposure. However, the association between indoor stove/fireplace   use and breast cancer risk is unknown. We hypothesized that   indoor stove/fireplace use in a Long Island, New York study   population would be positively associated with breast cancer and   differ by material burned, and the duration and timing of   exposure. We also hypothesized that the association would vary by   breast cancer subtype defined by p53 mutation status, and   interact with glutathione S-transferases GSTM1, T1, A1 and P1   polymorphisms. METHODS: Population-based, case-control resources   (1,508 cases/1,556 controls) were used to conduct unconditional   logistic regression to estimate adjusted odds ratios (OR) and 95%   confidence intervals (CI). RESULTS: Breast cancer risk was   increased among women reporting ever burning synthetic logs   (which may also contain wood) in their homes (OR = 1.42, 95% CI   1.11, 1.84), but not for ever burning wood alone (OR = 0.93, 95%   CI 0.77, 1.12). For synthetic log use, longer duration >7   years, older age at exposure (>20 years; OR = 1.65, 95% CI   1.02, 2.67) and 2 or more variants in GSTM1, T1, A1 or P1 (OR =   1.71, 95% CI 1.09, 2.69) were associated with increased risk.   CONCLUSIONS: Burning wood or synthetic logs are both indoor PAH   exposure sources; however, positive associations were only   observed for burning synthetic logs, which was stronger for   longer exposures, adult exposures, and those with multiple GST   variant genotypes. Therefore, our results should be interpreted   with care and require replication.

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