Steven Stellman - Cancer in World Trade Center responders: Findings from multiple cohorts and options for future study

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      Boffetta, P., Zeig-Owens, R., Wallenstein, S., Li, J., Brackbill,   R., Cone, J., Farfel, M., Holden, W., Lucchini, R., Webber, M.   P., Prezant, D., Stellman, S. D. 59 (2) 96-105-

      Abstract: BACKGROUND: Three longitudinal studies   of cancer incidence in varied populations of World Trade Center   responders have been conducted. METHODS: We compared the design   and results of the three studies. RESULTS: Separate analyses of   these cohorts revealed excess cancer incidence in responders for   all cancers combined and for cancers of the thyroid and prostate.   Methodological dissimilarities included recruitment strategies,   source of cohort members, demographic characteristics, overlap   between cohorts, assessment of WTC and other occupational   exposures and confounders, methods and duration of follow-up,   approaches for statistical analysis, and latency analyses.   CONCLUSIONS: The presence of three cohorts strengthens the effort   of identifying and quantifying the cancer risk; the heterogeneity   in design might increase sensitivity to the identification of   cancers potentially associated with exposure. The presence and   magnitude of an increased cancer risk remains to be fully   elucidated. Continued long-term follow up with minimal   longitudinal dropout is crucial to achieve this goal. Am. J. Ind.   Med. 59:96-105, 2015. (c) 2015 Wiley Periodicals, Inc.

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