Steven Stellman - Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)

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      Publication Details (including relevant citation   information):

      Mordukhovich, I., Beyea, J., Herring, A. H., Hatch, M., Stellman,   S. D., Teitelbaum, S. L., Richardson, D. B., Millikan, R. C.,   Engel, L. S., Shantakumar, S., Steck, S. E., Neugut, A. I.,   Rossner, P., Santella, R. M., Gammon, M. D. 124 (1)   30-38-

      Abstract: BACKGROUND: Polycyclic aromatic   hydrocarbons (PAHs) are widespread environmental pollutants,   known human lung carcinogens, and potent mammary carcinogens in   laboratory animals. However, the association between PAHs and   breast cancer in women is unclear. Vehicular traffic is a major   ambient source of PAH exposure. OBJECTIVES: Our study aim was to   evaluate the association between residential exposure to   vehicular traffic and breast cancer incidence. METHODS:   Residential histories of 1,508 participants with breast cancer   (case participants) and 1,556 particpants with no breast cancer   (control participants) were assessed in a population-based   investigation conducted in 1996-1997. Traffic exposure estimates   of benzo[a]pyrene (B[a]P), as a proxy for traffic-related PAHs,   for the years 1960-1995 were reconstructed using a model   previously shown to generate estimates consistent with measured   soil PAHs, PAH-DNA adducts, and CO readings. Associations between   vehicular traffic exposure estimates and breast cancer incidence   were evaluated using unconditional logistic regression. RESULTS:   The odds ratio (95% CI) was modestly elevated by 1.44 (0.78,   2.68) for the association between breast cancer and long-term   1960-1990 vehicular traffic estimates in the top 5%, compared   with below the median. The association with recent 1995 traffic   exposure was elevated by 1.14 (0.80, 1.64) for the top 5%,   compared with below the median, which was stronger among women   with low fruit/vegetable intake [1.46 (0.89, 2.40)], but not   among those with high fruit/vegetable intake [0.92 (0.53, 1.60)].   Among the subset of women with information regarding traffic   exposure and tumor hormone receptor subtype, the traffic-breast   cancer association was higher for those with   estrogen/progesterone-negative tumors [1.67 (0.91, 3.05) relative   to control participants], but lower among all other tumor   subtypes [0.80 (0.50, 1.27) compared with control participants].   CONCLUSIONS: In our population-based study, we observed positive   associations between vehicular traffic-related B[a]P exposure and   breast cancer incidence among women with comparatively high   long-term traffic B[a]P exposures, although effect estimates were   imprecise. Citation: Mordukhovich I, Beyea J, Herring AH, Hatch   M, Stellman SD, Teitelbaum SL, Richardson DB, Millikan RC, Engel   LS, Shantakumar S, Steck SE, Neugut AI, Rossner P Jr., Santella   RM, Gammon MD. 2016. Vehicular traffic-related polycyclic   aromatic hydrocarbon exposure and breast cancer incidence: the   Long Island Breast Cancer Study Project (LIBCSP). Environ Health   Perspect 124:30-38; http://dx.doi.org/10.1289/ehp.1307736.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/26008800