Steven Stellman - Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence

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      Publication Details (including relevant citation   information):

      White, A. J., Bradshaw, P. T., Herring, A. H., Teitelbaum, S. L.,   Beyea, J., Stellman, S. D., Steck, S. E., Mordukhovich, I., Eng,   S. M., Engel, L. S., Conway, K., Hatch, M., Neugut, A. I.,   Santella, R. M., Gammon, M. D. 89-90 185-192-

      Abstract: BACKGROUND: Despite studies having   consistently linked exposure to single-source polycyclic aromatic   hydrocarbons (PAHs) to breast cancer, it is unclear whether   single sources or specific groups of PAH sources should be   targeted for breast cancer risk reduction. OBJECTIVES: This study   considers the impact on breast cancer incidence from multiple PAH   exposure sources in a single model, which better reflects   exposure to these complex mixtures. METHODS: In a   population-based case-control study conducted on Long Island, New   York (N=1508 breast cancer cases/1556 controls), a Bayesian   hierarchical regression approach was used to estimate adjusted   posterior means and credible intervals (CrI) for the adjusted   odds ratios (ORs) for PAH exposure sources, considered singly and   as groups: active smoking; residential environmental tobacco   smoke (ETS); indoor and outdoor air pollution; and grilled/smoked   meat intake. RESULTS: Most women were exposed to PAHs from   multiple sources, and the most common included active/passive   smoking and grilled/smoked food intake. In multiple-PAH source   models, breast cancer incidence was associated with residential   ETS from a spouse (OR=1.20, 95%CrI=1.03, 1.40) and synthetic   firelog burning (OR=1.29, 95%CrI=1.06, 1.57); these estimates are   similar, but slightly attenuated, to those from single-source   models. Additionally when we considered PAH exposure groups, the   most pronounced significant associations included total indoor   sources (active smoking, ETS from spouse, grilled/smoked meat   intake, stove/fireplace use, OR=1.45, 95%CrI=1.02, 2.04).   CONCLUSIONS: Groups of PAH sources, particularly indoor sources,   were associated with a 30-50% increase in breast cancer   incidence. PAH exposure is ubiquitous and a potentially   modifiable breast cancer risk factor.

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