Owen Priest - Total Synthesis of Michellamines A-C: Important Anti-HIV Agents

Document created by Owen Priest on Dec 30, 2016
Version 1Show Document
  • View in full screen mode

  Publication Details (including relevant citation   information):

 

Hoye, Thomas. R., M. Chen, L. Mi, and Owen P. and Priest. 1994. "Total Synthesis of Michellamines A-C: Important Anti-HIV Agents."  Tetradedron Lett. 1994, 35, 8747-8750.

   

  Abstract:

Michellamines A-C I were prepd. by total synthesis in 7 and 16 linear steps from known and com. materials, resp. Key steps include i) palladium (O)-mediated biaryl coupling, ii) silver oxide promoted oxidative 1-naphthol coupling to an atropisomeric mixt. of cross-ring quinones (indigoids), and iii) simultaneous per-debenzylation/reductive bleaching to the central 2,2'-binaphthol.

  Address (URL):

 

Attachments

    Outcomes