Thomas Welton - Synthesis of an elaborated heliquinomycin isocoumarin moiety

Document created by Thomas Welton on Feb 10, 2017
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  Publication Details (including relevant citation   information):

  Thrash, Thomas P., Welton, Thomas D., Behar, Victor 41  (1) 29-31

  Abstract: Synthesis of a fully functionalized   isocoumarin moiety 2 of DNA helicase inhibitor heliquinomycin (1)   is reported. The key step is a modified condensation reaction of   diethyl bromomalonate with readily accessible phthalaldehydic   acid derivative 3. Introduction of an allyl side chain is   accomplished by Claisen rearrangement of allyl phenyl ether 8.

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