Thomas Welton - Synthesis of an elaborated heliquinomycin isocoumarin moiety

Document created by Thomas Welton on Feb 10, 2017
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  Publication Details (including relevant citation   information):

  Thrash, Thomas P., Welton, Thomas D., Behar, Victor 41  (1) 29-31

  Abstract: Synthesis of a fully functionalized   isocoumarin moiety 2 of DNA helicase inhibitor heliquinomycin (1)   is reported. The key step is a modified condensation reaction of   diethyl bromomalonate with readily accessible phthalaldehydic   acid derivative 3. Introduction of an allyl side chain is   accomplished by Claisen rearrangement of allyl phenyl ether 8.

  Address (URL): http://www.sciencedirect.com/science/article/pii/S0040403999019668

 

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