List of publications

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    1. Champeil E, Paz MM, Ladwa S, Clement CC, Zatorski A, Tomasz M.  Synthesis of an Oligodeoxyribonucleotide Adduct of Mitomycin C by the Postoligomerization Method via a Triamino Mitosene.  J Am Chem Soc. 2008 Jun 28.

     

    2. Maitra R, Clement CC, Crisi GM, Cobelli N, Santambrogio L. Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation. PLoS ONE. 2008 Jun 18;3 (6):e2438 (shared authorship).

     

    3.  Goeckeler JL, Petruso AP, Aguirre J, Clement CC, Chiosis G, Brodsky JL. The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.   FEBS Lett. 2008 Jul 9;582(16):2393-6.

     

    4.  Kang Y, Taldone T, Clement CC, Fewell SW, Aguirre J, Brodsky JL, Chiosis G. Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorg Med Chem Lett.  2008 Jul 1;18 (13):3749-51.

     

    5.  Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G.  Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.  Nat Chem Biol. 2007 Aug. 3 (8):498-507.

     

    6.  Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorg Med Chem Lett.2006 Sep. 1;16 (17): 4515-8.

     

    7.  Utzat CD, Clement CC, Ramos LA, Das A, Tomasz M, Basu AK. DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo. Chem Res Toxicol. 2005 Feb;18 (2):213-23. (shared authorship).

     

    8. Subramaniam G, Paz MM, Suresh Kumar G, Das A, Palom Y, Clement CC, Patel DJ, Tomasz M. Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry. 2001 Sep. 4;40 (35):10473-84.

     

    9. Cristina C. Clement & Manfred Philipp. Structure-Based Design & Structure-Activity Relationships of D-Phe-Pro-D-Arg-P1'-CONH2 Tetrapeptides Inhibitors of Thrombin.  Understanding Biology Using Peptides, Sylvie E. Blondelle (Editor). Proceedings of American Peptide Society, 2005.

     

    10. Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.  Cancer Cell. 2006 Oct.10 (4):321-30.

     

    11. Clement CC, Babinska A, Kornecki E, Philipp M.   Isothermal titration calorimetry and inhibition of platelets aggregation by [D-Phe/(transcinnamoyl)-Pro-D-Arg-P1'-CONH2] peptides inhibitors of thrombin. Adv Exp Med Biol, 2009;611:579-80.

     

    12. Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.  Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer modelsProc Natl Acad Sci U S A. 2009 May 5.

     

    13.  Cristina C. Clement, Anna Babinska, Yigal H.Ehrlich, Manfred Philipp, Elizabeth Kornecki. 

    Peptides Inhibitors of F11R/JAM-A Adhesion Molecules and Potent Anti-atherosclerosis Drugs.

    Proceedings of the 21st American Peptide Symposium, 2009.

     

    14.  Radhashree Maitra, Cristina C. Clement, Brian Scharf, Giovanna M, Crisi, Jose Martinez, Sriram Chitta  Neil Cobelli and Laura Santambrogio. Endosomal disruption plays a key role in UHMWPE induced osteolysis; Journal of Molecular Immunology, October 2009.

     

    15.  Clement CC, Cannizzo ES, Nastke MD, Sahu R, Olszewski W, Miller NE, Stern LJ,

    Santambrogio L.  An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma. PLoS One. 2010 Mar 26;5(3):e9863.

     

    16. Clement CC, Rotzschke O, Santambrogio L. The lymph as a pool of self-antigens. Trends Immunol. 2011 Jan;32(1):6-11. Epub 2010 Dec 1. 

     

    17. Ahn JH, Luo W, Kim J, Rodina A, Clement CC, Aguirre J, Sun W, Kang Y, Maharaj R, Moulick K, Zatorska D, Kokoszka M, Brodsky JL, Chiosis G.  Design of a Flexible Cell-Based Assay for the Evaluation of Heat Shock Protein 70 Expression Modulators.  Assay Drug Dev Technol. 2010 Dec 6.

     

    18. Carvalho Figueiredo A, Clement CC, Philipp M, Barbosa Pereira PJCrystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin.  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):54-8. Epub 2010 Dec 21.

     

    19.  Sahu R, Kaushik S, Clement CC, Cannizzo ES, Scharf B, Follenzi A, Potolicchio I, Nieves E, Cuervo AM, Santambrogio L.  Microautophagy of cytosolic proteins by late endosomes.  Dev Cell. 2011 Jan 18;20(1):131-9.

     

    20. Cannizzo ES, Clement CC, Sahu R, Follo C, Santambrogio L. J Proteomics. 2011 Jun 21.