Daichi Nakamura - Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol

Version 3

      Publication Details (including relevant citation   information):

        Adv. Synth. Catal. 2016,    358 (14), pp 2345–2351

      Abstract:

        The asymmetric cross-aldol reaction of dichloroacetaldehyde with   aldehyde pronucleophiles proceeds in the presence of a   trifluoromethyl-substituted diarylprolinol to afford   γ,γ-dichloro-β-hydroxy aldehydes in good yield with excellent   enantioselectivity. The obtained products are useful synthetic   intermediates; they were successfully converted to form chiral   alkynes and dichloroalkenes.

      Address (URL): http://dx.doi.org/10.1002/adsc.201501111