Publication Details (including relevant citation information):
Adv. Synth. Catal. 2016, 358 (14), pp 2345–2351
The asymmetric cross-aldol reaction of dichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of a trifluoromethyl-substituted diarylprolinol to afford γ,γ-dichloro-β-hydroxy aldehydes in good yield with excellent enantioselectivity. The obtained products are useful synthetic intermediates; they were successfully converted to form chiral alkynes and dichloroalkenes.
Address (URL): http://dx.doi.org/10.1002/adsc.201501111