Jean-Claude Bunzli - Lanthanide light for biology and medical diagnosis

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  B nzli,J.-C.G. Journal of Luminescence  2016 170 (3) 866-878

  Abstract: Optical imaging emerges as a vital   component of the various techniques needed to meet the stringent   requirements of modern bioanalysis and bioimaging. Lanthanide   luminescent bioprobes (LLBs) have greatly contributed to this   field during the past 35 years because they have definite   advantages such as little or no photobleaching and, thanks to   time-gated detection, high sensitivity. The review summarizes the   numerous tools offered by LLBs under their various forms,   coordination compounds, nanoparticles, upconverting nanoparticles   and their bioconjugates. It then focuses on biosensing, including   point-of-care analysis, and then on both in vitro and in vivo   bioimaging with visible and NIR light. The last section compares   the performances of LLBs versus those of other commonly used   bioprobes (organic dyes, quantum dots, transition metal   complexes). It is concluded that although LLBs will not replace   all of existing bioprobes, they add invaluable new specific   technologies to the biologist and medical doctor toolboxes. A   good deal of improvements are achieved through nanotechnologies,   which demonstrates that progresses in biosciences depends on the   intersection of different disciplines, photophysics, chemistry,   biochemistry, nanotechnology, and materials science.

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