Jean-Claude Bunzli - A ruthenium-based metallostar: synthesis, sensitized luminescence and H-1 relaxivity

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  Moriggi,L., Aebischer,A., Cannizzo,C., Sour,A., Borel,A.,   Bunzli,J.C.G., Helm,L. Dalton Transactions  2009 (12) 2088-2095

  Abstract: Ru-based metallostars   Na-4{Ru[Ln(2)bpy-DTTA(2)(H2O)(4)](3)} (Ln = Y, Gd, and Eu) have   been self-assembled in aqueous solution and their relaxivity and   optical properties unravelled. The synthesis and the purification   of the new, highly stable heptametallic entities have been   optimized for the diamagnetic Y3+ complex and followed by H-1   NMR. The europium(III) ruthenium-based metallostar   {Ru[Eu(2)bpy-DTTA(2)(H2O)(4)](3)}(4-) displays sensitized D-5(0)   -> F-7(J) luminescence upon excitation of the   tris(2,2'-bipyridyl) ruthenium(II) unit in the ultraviolet around   293 nm, as well as in the visible around 450 nm ((MLCT)-M-1   state). NMRD profiles at two temperatures (25 degrees C and 37   degrees C) were performed on   {Ru[Gd(2)bpy-DTTA(2)(H2O)(4)](3)}(4-). NMRD pro. les of the   ruthenium-based {Ru[Gd(2)bpy-DTTA(2)(H2O)(4)](3)}(4-) and the   iron-based {Fe[Gd(2)bpy-DTTA(2)(H2O)(4)](3)}(4-) metallostars   were fitted with SBM theory coupled to the model-free   Lipary-Szabo method for internal motion as well as with the   modified Florence approach. Comparison of both fitting methods   shows that the Florence approach is able to fit NMRD profiles up   to 100 MHz, fails however at higher frequencies because it does   not account for internal motion. Overall, the results detailed   point to the heptametallic self-assembled edifices being   potential relaxivity and luminescence bimodal bioprobes for use   in animal models

  Address (URL): WOS:000263990200006