Jean-Claude Bunzli - Use of dipicolinate-based complexes for producing ion-imprinted polystyrene resins for the extraction of yttrium-90 and heavy lanthanide cations

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      Publication Details (including relevant citation   information):

      Chauvin,A.S., Bunzli,J.C.G., Bochud,F., Scopelliti,R.,   Froidevaux,P. Chemistry-A European Journal  2006 12 (26) 6852-6

      Abstract: Highly selective separation of yttrium   (and lanthanides) is of interest for the design of   radiopharmaceuticals, and an efficient method based on the   ion-imprinting concept is proposed here. The synthesis and   structural, thermodynamic and photophysical characterization of   complexes of trivalent yttrium and lanthanides with two new vinyl   derivatives of dipicolinic acid, HL1 and L2, are described. The   feasibility of using ion-imprinted resins for yttrium and   lanthanide separation is demonstrated. The resins were obtained   by copolymerization with styrene and divinylbenzene and   subsequent acid treatment to remove the metal ion.   High-resolution Eu luminescence experiments revealed that the   geometry of the complexation sites is well preserved in the   imprinted polymers. The ion-imprinted polymer based on HL1 proved   to be particularly well adapted for yttrium extraction, having a   sizeable capacity (8.9 +/- 0.2mgg(-1) resin) and a fast rate of   extraction (t(1/2) = 1.7min). In addition, lighter and heavier   lanthanide ions are separated. Finally, the resin displays high   selectivity for yttrium and lanthanide cations against alkali and   alkaline earth metals. For instance, in a typical experiment, 10   ing of yttrium was extracted from 5 g of milk ash sample by 2 g   of the resin. The good separation properties displayed by the   resin based on HL1 open interesting perspectives for the   production of highly pure Y-90 and radiolanthanides for medical   applications, and for trace analysis of these radiochemicals in   food and in the environment

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