Jean-Claude Bunzli - Enhanced imaging properties of a Gd-III complex with unusually large relaxivity

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  Publication Details (including relevant citation   information):

  Fatin-Rouge,N., Toth,E., Meuli,R., Bunzli,J.C.G. Journal of   Alloys and Compounds 2004 374  (1-2) 298-302

  Abstract: MRI contrast properties of   self-aggregated nanoparticles made from Gd-III and   1,2,4,5-tetrakis(pyrazol-1-yl-methyl-3-carboxylate)benzene (L)   are investigated. Viscosity of GdL2 suspensions and   size-characteristics of GdL2 nanoparticles allow an estimate of   their large rotational correlation time. Moreover, two to three   H2O molecules are bound, on average, to Gd-III ions, as deduced   from O-17 NMR titration of the Dy-III analogue. The large   relaxivity of the particles, along with the prominent peak in the   range 20-60 MHz, are the consequence of these two properties.   Longitudinal (r(1)) and transverse (r(2)) relaxivities are   determined as a function of monomer concentration at 20degreesC   and 20 MHz. The ratio r(1)/r(2) appears to be favorable for MR   imaging using T-1-weighted gradient echo sequences. According to   preliminary tests conducted under physiological conditions, the   GdL2 nanoparticles have some potential as contrast agent provided   their stability can be increased. (C) 2003 Elsevier B.V. All   rights reserved

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