Andrew Lees - T cell-independent antigens type 2

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  Publication Details (including relevant citation   information):

  Annual Review of Immunology 13:655, 1995

  Mond, J. J.  Lees, A., Snapper, C. M.


  In this review we have attempted to define the characteristics of   TI-2 antigens that enable them to stimulate antibody production   in the absence of T cell help. One of the most critical   properties of this group of antigens is their ability to deliver   prolonged and persistent signaling to the B cell. This by itself   is not however sufficient to stimulate Ig synthesis, and they   must therefore stimulate non-T cells to interact with the B cells   either directly or indirectly via cytokine production. There is   evidence implicating the NK cell and T cell as playing this   important role in response to TI antigens. Furthermore, we   discuss the importance of cytokines such as IL-3, GMCSF, and   IFN-gamma, which significantly enhance antibody production by   these antigens. Finally, we present evidence demonstrating that B   cell activation via TI stimuli does not play merely a permissive   role in allowing for cell cycle entry and enhanced responsiveness   to other stimuli. Rather, the nature of the B cell activating   signal is critical in determining the quantitative and   qualitative profile of Ig isotype production.

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