Solvent Suitability for Acetonitrile as per ACS method_UHPLC & HPLC.docx

File uploaded by Roshan Shinde on Jul 22, 2019Last modified by Roshan Shinde on Sep 24, 2020
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Hi All,

Anyone please help me in below issue.

Please find attached LC chromatograms of Solvent suitability of Acetonitrile solvent done as per ACS method on UHPLC and HPLC. I got the pattern as per attached chromatograms. So I need to understand why I got negative baseline in UHPLC when 100% ACN was running in programme. Kindly share standard chromatogram if available.


Roshan Shinde