DFT, cytotoxicity and molecular docking studies of (E)-2((2- hydroxybenzylidene) amino-3-mercaptopropanoic acid and its Co(II), Ni(II) and Cu(II) complexes

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my poster in page 17  , Kathmandu Symposia on Advanced Materials (KaSAM)-2018; October 26-29, 2018, Kathmandu, Nepal

 

DFT, cytotoxicity and molecular docking studies of (E)-2((2-
hydroxybenzylidene) amino-3-mercaptopropanoic acid and its Co(II),
Ni(II) and Cu(II) complexes
M.M. El-ajaily1*, S.S. Mahmoud2, R.N. El-daghare1, A.K. Sarangi3, R.K. Mohapatra3* and T.H.
Al-Noor
4
1Chemistry Department, Faculty of Science, Benghazi University, Benghazi, Libya
2Chemistry department, Faculty of Science, Cairo University, Giza, Egypt
3Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India
4Chemistry Department, Ibn-Al-Haithem College of Education for Pure Science, Baghdad University,
Baghdad, Iraq
*E-mail: ranjank_mohapatra@yahoo.com
The cytotoxicity studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid
(HL) derived from the condensation of 2-hydroxybenzaldehyde and L-cysteine and its Co(II), Ni(II)
and Cu(II) complexes have been reported against four cancer cell lines. The evaluation of the growth
inhibitory on human cancer cells is studied for the chelates against HCT-116, MCF-7, HFB-4,
HepG-2 cell lines. The obtained results (
Fig. 1) revealed that the compounds are active against human
hepatocellular carcinoma cell line (HepG-2).

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