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suo_zucai
New Contributor

Assays for cisplatin-DNA adducts

Cisplatin is an anticancer drug. Can anyone tell me the best assays to identify and quantitate cisplatin modification of a short DNA oligomer? Thanks.

-Zucai Suo

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srikanthkotapati
New Contributor

Re: Assays for cisplatin-DNA adducts

Please go through this article:

Development of an Ultraperformance Liquid Chromatography/Mass

Spectrometry Method To Quantify Cisplatin 1,2 Intrastrand
Guanine-Guanine Adducts

Chem. Res. Toxicol. 2009, 22, 905–912

Hope this answers your question

regards

Srikanth

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