Member Profile
Name: Bernd Lepenies
Country: Germany
City: Potsdam Golm
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Technical Division Membership: Biological Chemistry Division
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Career Stage: Professional
Research and Special Interests: My group "Glycoimmunology" at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, focuses on the impact of complex oligosaccharide structures on inflammatory processes in the body. In our immune system, there are different classes of carbohydrate-binding receptors (so-called lectins) that recognize specific glycan structures on glycoproteins and glycolipids. C-type lectin receptors (CLRs) represent a large lectin receptor superfamily predominantly expressed on cells of the innate immune system. CLRs recognize evolutionary conserved glycan structures on pathogens and play a crucial role in the initiation of a protective immune response during infections. Furthermore, they are important for the maintenance of tolerance to autoantigens. In my group, the function of CLRs is investigated by using murine models of infection and autoimmunity. We intend to identify new ligands of CLRs and utilize CLRs for a specific targeting of antigen-presenting cells. Finally, we want to elucidate how CLRs influence inflammatory processes in vivo. This should lead to new strategies for a specific modulation of ongoing immune responses.
Area of Expertise: Biochemistry, Immunology, Parasitology
Years of Expertise: 1-5
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‎12-15-2020 04:26 AM