Name:
Raj Singh
Country:
United Kingdom
City:
Leicester
State/Province:
ACS Member:
false
Local Section:
International Chapter:
Technical Division Membership:
Chemical Toxicology Division
Technical Division Membership Emeritus:
Subdivision Member:
ACS Activities:
Company/Institution Name:
Career Stage:
Professional
Research and Special Interests:
The focus of my research is to investigate the formation of DNA adducts in humans following exposure to carcinogenic chemical compounds from occupational, lifestyle, environmental and dietary sources. DNA adducts are formed by the covalent interaction of carcinogens (genotoxins) with the purine and pyrimidine bases that are present in DNA. A mutation may result following DNA replication if the DNA adduct is not repaired and subsequent initiation of the carcinogenic process. By developing sensitive analytical techniques for detecting DNA adducts arising from exposure to both endogenously formed eg. by oxidative stress and exogenous genotoxic agents we would like to investigate the biological significance of DNA damage and gain further insight into the mechanism of the carcinogenic process.
http://www.le.ac.uk/cm/staff/rs25_full.html
Area of Expertise:
Chemical Carcinogenesis, DNA adducts, Mass Spectrometry
Years of Expertise:
16-20