Research led by the University of Birmingham, published in Science Translational Medicine, has discovered that a drug commonly used to treat patients with either obesity or Type II diabetes could be used as a novel new way to lower brain pressure.
Over a three-year period, researchers at the University of Birmingham examined the GLP-1 agonist drugs, which were used in the treatment of diabetes and obesity, could reduce intracranial pressure in an animal model of raised brain pressure. Corresponding author Dr Alexandra Sinclair said that the GLP-1 agonist extendin-4 significantly reduces brain pressure rapidly and dramatically, by around 44 percent with significant effects from just 10 minutes of dosing. What's more, they found that the effects last at least 24 hours. The University of Birmingham is now due to begin a clinical trial to test GLP-1 agonist drug in patients with raised brain pressure.