Alex Dean

Therapeutic Function of Natural Compounds

Blog Post created by Alex Dean on Jan 16, 2018

t is a strange phenomenon that there is an increasing fondness for natural stuff, in particular, food and cosmetic products produced from natural sources without added artificial ingredients. In this sense, natural products usually refer to purified organic compounds isolated from natural sources.


Natural compounds receive world recognition for their therapeutic function. A great example is that various herbs were already used in the traditional Chinese medicine (TCM) since ancient times. According to a report published by the American Chemical Society, natural products or their novel structures are broadly and frequently utilized for the purpose of discovering and developing the final drug entity.


For example, in the area of cancer, over the time frame from around the 1940s to the end of 2014, 131 (75%) of the 175 small molecules approved are other than synthetic, among which, 85 (49%) are actually either natural products or directly derived from natural products. In other areas, the influence of natural product structures is still quite remarkable, with, as expected from prior information, the anti-infective area being dependent on natural products and their structures. It is wished that more areas of natural product research should be greatly expanded to achieve more findings.


In this article, we will get a quick look at two natural compounds together with their therapeutic function.


P-Menthane-3,8-diol (Natural)

P-Menthane-3,8-diol, also called PARA-MENTHANE-3,8-DIOL, PMD, 1-(2-Hydroxy-4-methylcyclohexyl)-1-methylethanol, is found in small quantities in the essential oil from the leaves of Corymbia citriodora (formerly known as Eucalyptus citriodora). P-Menthane-3,8-diol smells similar to menthol and has a cooling feel.


P-Menthane-3,8-diol is used to make products that has the function of repelling insects, such as mosquitoes. However, unlike other pesticides, it can be applied to human skin or clothing, not causing any harm to humans or the environment. Generally speaking, it can be used in two types: a spray and a lotion in terms of consumer pesticide products. Of course it should be used under instructions.


Ginsenoside Rd

Ginsenoside Rd is a natural triterpenoid compound found in the roots of Panax ginseng, which has a long history of applicaiton in traditional medicine that has led to the study of pharmacological effects of ginseng compounds. It belongs to a class of natural product steroid glycosides and triterpene saponins. As a class, ginsenosides exhibit a large variety of subtle and difficult-to-characterize biological effects when studied in isolation.


Ginsenoside Rd shows antioxidant activities. It has been observed to increase internal antioxidant enzymes and act as a free-radical scavenger. There are also studies in animal models suggesting that ginsenosides have neuroprotective properties and could be useful in treating neurodegenerative disease such as Alzheimer's and Parkinson's diseases. Besides, ginsenoside Rd is reported to be effective on the cardiovascular system, the central nervous system and the immune system. But still, more remains to be explored and discovered.