Alex Dean

The Anti-cancer Effect of Kaempferol

Blog Post created by Alex Dean on Feb 21, 2019

Cancer is the biggest energy for all human beings, as always. Although surgery, radiation treatments, and chemotherapy all have shown remarkable efficacy in cancer treatments, yet the strong side effects of them cannot be neglected. Not to mention vomiting and hair loss, in most cases, patients are facing the risk of cancer recurrence, more often than not. 

 

In a pursuit to find a better, or seemingly better, cure for cancer, generations of scientists and researchers have made their endeavors to this great cause. And their efforts have been rewarded.

They find flavonoids may have some anti-cancer effects. Flavonoids are polyphenolic compounds commonly found in plants and constitute a significant part of the human diet. Long before, the antioxidant and anti-inflammatory capacities of these compounds were documented, and many showed cancer-fighting potentials. The reason is that: flavonoids were reported to inhibit VEGF expression, cancer cell proliferation and angiogenesis.

 

Among all flavonoids, kaempferol is a special one. As a member of the flavonols, kaempferol is abundantly found in tea, broccoli, apples, strawberries, and beans. It has been demonstrated to invoke several different mechanisms in the regulation of cancer cells. Not only is kaempferol a potent promoter of apoptosis, but it also modifies a host of cellular signaling pathways. More importantly, kaempferol is much less toxic to normal cells in comparison to standard chemotherapy drugs. For those who would like to keep their normal cells from unnecessary hurt, kaempferol might be a good choice.

 

Food sources of kaempferol

 

Generally, kaempferol is found in many plants, plant-derived foods, and traditional medicines. Common foods that contain kaempferol include: apples, grapes, tomatoes, green tea, potatoes, onions, broccoli, Brussels sprouts, squash, cucumbers, lettuce, green beans, peaches, blackberries, raspberries, and spinach, just to name a few.

 

Broad anti-cancer effects of kaempferol

 

Kaempferol has been proved to be effective in combating cancer, but you may wonder what kind of cancers they are. Here we sort out some types for your reference.   

 

Breast cancer

Kaempferol has also been found to induce apoptosis in breast cancer cells through extracellular signal-regulated kinase ½ activation and up-regulation of p53. Because kaempferol has been shown to interact with the estrogen receptor pathway and alter signaling in order to help slow growth, while Estrogen receptors are important in both maintaining a normal mammary gland, and in the development of primary and secondary breast cancer.

 

Ovarian cancer

Existing evidence has shown that kaempferol can “inhibit VEGF production and suppress ovarian cancer cell metastasis in vitro”.

 

Leukemia

Kaempferol has been shown to reduce growth in pro-myelocytic leukemia cells through altering the cell cycle.

 

Besides, kaempferol are effective in other cancers including lung cancer, diabetes, cardiovascular disorders, etc.

 

This article is shared by BOC Sciences, a supplier of a comprehensive collection of chemicals ranging from celastrol to anastrozole, maraviroc to deoxynivalenol.

 

 

Outcomes