Member Profile
Name: Cristina Corina Clement
Country: USA
City: Bronx
State/Province: NY
ACS Member: Member
Local Section: L108,New York
International Chapter:
Technical Division Membership: D503,Biological Chemistry Division;D518,Medicinal Chemistry Division;D519,Biochemical Technology Division
Technical Division Membership Emeritus:
Subdivision Member:
ACS Activities: 1. Invited presentations (talks): • Division of Chemical Toxicology, American Chemical Society, National Meeting, September 2003. • Division of Physical/Biophysical Chemistry, American Chemical Society, Middle Atlantic regional meeting, May 2008. 2. Posters presentations: 2004-2011
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Career Stage: Professional
Research and Special Interests: 1. Nov. 2005 – Jul. 2009. Postdoctoral training, lab of Dr. Gabriela Chiosis, Sloan Kettering Institute (NYC), Molecular Pharmacology and Medicine Departments. Significant training acquired in cell-based assays, fluorescence polarization, and biochemical investigations of anti-cancer drugs, specifically inhibitors of Hsp-70 and Hsp-90 ATP-ase activity. Personal contribution to these projects included: A).Development of fluorescence polarization and fluorescence-based ATP-ase assays for monitoring the Hsp-70 and Hsp-90 ATP-ase activities. B). Development of cell-based assays to study the effect of different small organic molecules against some breast (MDA-231, MDA-468, SKbr-3) and small lung cancer cell lines. 2. Jul. 2007 – present. Postdoctoral training, lab of Dr. Laura Santambrogio, Albert Einstein College of Medicine of Yeshiva University, Department of Pathology. Important training acquired in peptidomic andproteomics of human lymph, plasma, sinovial fluid, using high resolution electrospray ionization mass spectroscopy methods (ESI-LTQ). Also, MALDI and MS/MS sequencing of naturally processed peptides using advanced algorithms for database searching (Mascot, Sequest). Personal contribution to these projects included: A) Development of new assays for investigating collagen-I processing by metalloproteases, cathepsins (B,D,S and L), and lysosomal, endosomal and plasma membranes purified from human primary dendritic cells (subcellular fractionations of plasma membranes, lysosomes and endosomes). B) Development of new intrinsic Tyr fluorescence assay for monitoring ligand binding to Toll receptor 2. 3.
Area of Expertise:
Years of Expertise: 6-10
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‎12-15-2020 04:26 AM