Name:
Edward E Yonan
Country:
USA
City:
Wilmette
State/Province:
IL
ACS Member:
Member
Local Section:
L501,Chicago
International Chapter:
Technical Division Membership:
Technical Division Membership Emeritus:
Subdivision Member:
ACS Activities:
Company/Institution Name:
Career Stage:
Professional
Research and Special Interests:
PUBLICATIONS
• Development of a Large Scale Process for an HIV Protease inhibitor. Journal of Organic Process Research & Development, 1998.
• Convenient Asymmetric Synthesis of the Unnatural Amino Acid 2, 6-dimethyl-L-Tyrosine Synthesis. NO.8, 1992.
• Synthesis of 2-[(2-Bromo-6-chlorophenyl) amino] benzene acetic acid sodium salt, an impurity in the Anti-inflammatory Agent Diclofenac sodium. Journal of Technical Community Monsanto, 1992.
• Chemistry and Structure-Activity Relationships of C-17 Unsaturated 18-Cycloalkyl and Cycloalkenyl Analogues of Enisoprost. Identification of a Promising New Antiulcer Prostaglandin. Journal of Medicinal Chemistry, 1990.
• Gave over 15 posters and papers at the ACS national meeting and TCM symposium.
• Author of over 110 in-house technical reports.
PATENTS
• Crystalline form of 4-[5-methyl-3-phenylisoxazol-4-yl] benzene sulfonamide,
• U. S. Patent No. 6,441.014
• Processes for preparation of 9,11-epoxy steroids and intermediates useful therein,
• U. S. Patent No. 6,610,844
• 5. beta.-cyano-substituted steroid compounds. U.S. Patent No.6,335,441
• Method and apparatus for preparation of chiral beta amino acids using penicillin G acyla.se,
• U. S. Patent No. 6,214,609
• Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein,
• U. S. Patent No. 6,331,622
• Process for Preparation of 9,11-Epoxy Steroids (Inspra) and Intermediates Useful Therein,
• U. S. Patent No. 6,630,587 B2
• Process for Preparation of 9,11-Epoxy Steroids (Inspra) and Intermediates Useful Therein,
• U. S. Patent No. 6,586,591 B2
• Purification and Crystalline form of 4-{5-methyl-3-Phenylisoxazol-4-YL} Benzene sulfonamide (Valdecoxib), U.S. Patent No. 6,441,014 B2.
• Keto-Substituted Steroid Compounds (Inspra), U. S. Patent No. 6,258,946 B1.
• Discovery of Novel Rearrange Ring and Preparation of 9, 11-Epoxy Steroid (Inspra) and Intermediates, U. S. Patent No. 6,180,780 B1.
• Process for the Preparation of 9, 11-Epoxy Steroid (Inspra) and Intermediates, U.S. Patent No. 5,981,744.
• Process for the Synthesis of Z- Asp artic Acid, U.S. Patent No. 4,293,706.
• alpha.-Aryl-alpha., .alpha.-bis [.omega.-(disubstituted amino) alkyl] acetamides and related compounds, U.S. Patent No.4, 107,205.
• alpha.-Aryl-.alpha., .alpha.-bis [.omega.- (disubstituted amino)alkyl]acetamides and related compounds, U. S. Patent No. 4,153,797.
Area of Expertise:
Senior Research Scientist, over 30 years of experience in the pharmaceutical industry. Utilization of organic chemistry in the design and synthesis of new chemical processes and/or the improvement of existing chemical processes; follow-up research leads through process development, pilot plant and into manufacturing. Developed and optimized synthetic routes for potential active pharmaceutical ingredients (API) and intermediates for (i-NOS, MMP, Celebrex, Bextra, Dynastat injectable Eplerenone, HIV, Steroids and Prostaglandin) and explored new and improved methods for their synthesis. The newly developed processes for (Celebrex, Bextra, Dynastat injectable COX-2 inhibitor and Inspra for hypertension) were transferred from the laboratory to pilot plant and manufacturing to prepare multi-kilogram quantities of both drug substance and drug API in support of preclinical and clinical studies. Authored several scientific publications and is listed as inventor on sixteen United State Patents.
Years of Expertise:
26 or more