Medicharla V Jagannadham

improving the de novosequencing efficiency of peptides using mass spectromerty

Blog Post created by Medicharla V Jagannadham on Mar 9, 2017

Chemical modification of peptides influences the fragmentation of peptides in mass spectrometry. Using different chemical modifications , we are trying to improve the de novo sequencing efficiency of peptides. This is very useful in proteomics.

Recently. our research is focused on chemical modification of peptides followed by Mass spectrometry. This helped improving the formation of certain type of ions (b-ions & y-ions) and improved the efficiency of de novo sequencing.

  1. Kulkarni, H.M., Ramesh, V., Srinivas, R. and Jagannadham, M.V. (2010) Proteomics Insights 3: 1-16