John Garner

History of PLGA in FDA approved products.

Blog Post created by John Garner on May 27, 2016

Since PLGA is sold at PolySciTech (www.polyscitech.com), I often receive questions about what products have PLGA in them that have been approved by FDA. Below is a quick list of these. As can be seen, there is a long and successful history of using PLGA as a safe and effective drug carrier system.

 

Product Name

Drug

Type

Duration

Dose

Approved

Zoladex

Goserelin

Solid implant

1,3 months

  1. 3.6 mg/month

1989

Lurpon

Leuprolide

Microparticle

1-4 months

  1. 7.5 mg/month

1989

Sandostatin

Octreotide

Microparticle

1 month

20 mg/month

1998

Atridox

Doxycycline

In situ gel

1 week

  1. 42.5 mg/week

1998

Nutropin

Somatotropin

Microparticle

1 month

  1. 13.5 mg/month

1999

Trelstar

Triptorelin

Microparticle

1-6 months

  1. 3.75 mg/month

2000, 2010

Superfact

Buserelin

Solid implant

2,3 months

  1. 3.15 mg/month

2000

Somatuline

Lanreotide

Microparticle

1 month

60 mg/month

2000

Arestin

Minocycline

Microparticle

2 weeks

  1. 0.5 mg/week

2001

Eligard

Leuprolide

In situ gel

1-6 months

  1. 7.5 mg/month

2002

RisperidalConsta

Risperidone

Microparticle

2 weeks

  1. 12.5 mg/week

2003

Vivitrol

Naltrexone

Microparticle

1 month

380 mg/month

2006

Ozurdex

Dexamethasone

Solid implant

3 months

  1. 0.23 mg/month

2009

Propel

Mometasone

Solid implant

1 month

  1. 370 mg/month

2011

Bydureon

Exenatide

Microparticles

1 week

2 mg/week

2012

Lupaneta Pack

Leuprolide

Microparticles

3 months

  1. 3.75 mg/month

2012

 

Outcomes