John Garner

PEG-PLGA from PolySciTech used in development of iron-chelating micelle system to treat bacterial infections

Blog Post created by John Garner on Jul 12, 2018

Qiao 2018 iron bacteria chelate polyscitech.JPG

Iron is an essential nutrient for bacteria and plays a significant role in the growth and development of bacterial biofilm. One means of treating bacterial infections and diseases is to chelate out iron, thus making it unavailable for bacterial use. Recently, researchers at University of Georgia and University of Wisconsin–Madison utilized mPEG-PLGA (PolyVivo AK010) and PLGA-PEG-NH2 (PolyVivo AI058) from PolySciTech (www.polyscitech.com) as part of forming an iron-chelating micelle for treatment of bacterial infections. This research holds promise to provide for improved therapies against cystic fibrosis and other bacterial diseases. Read more: Qiao, Jing, Max Purro, Zhi Liu, and May P. Xiong. "Terpyridine-Micelles for Inhibiting Bacterial Biofilm Development." ACS infectious diseases (2018). https://pubs.acs.org/doi/abs/10.1021/acsinfecdis.8b00091

“Iron plays a critical role in bacterial infections and is especially critical for supporting biofilm formation. Until recently, Fe(III) was assumed to be the most relevant form of iron to chelate in therapeutic antimicrobial strategies due to its natural abundance under normal oxygen and physiologic conditions. Recent clinical data obtained from cystic fibrosis (CF) patients found that there is actually quite an abundance of Fe(II) present in sputum and that there exists a significant relationship between sputum Fe(II) concentration and severity of the disease. A biocompatible mixed micelle formed from the self-assembly of poly (lactic-co-glycolic acid)-block-methoxy poly(ethylene glycol) (PLGA-b-mPEG) and poly(lactic-co-glycolic acid)-block-poly(terpyridine)5 [PLGA-b-p(Tpy)5] polymers was prepared to chelate Fe(II) (Tpy‒micelle). Tpy-micelles showed high selectivity for Fe(II) over Fe(III), decreased biofilm mass more effectively under anaerobic conditions at >4 µM Tpy-micelles, reduced bacteria growth in biofilms by >99.9% at 128 µM Tpy-micelles, effectively penetrated throughout a 1-day old biofilm and inhibited biofilm development in a concentration-dependent manner. This study reveals that Fe(II) chelating Tpy-micelles are a promising addition to Fe(III) chelating strategies to inhibit biofilm formation in CF lung infections.”

-

New whitepaper on acrylate-modified HMMC (AI147) use for forming UV-cured hydrogels available. Hydrogels are a class of polymers with exciting potential to provide for tissue-engineering or cell-growth capabilities. Recently, a whitepaper “AI147 Photocrosslinkg application” has been released detailing the use of PolyVivo AI147 to create UV-curable hydrogels. See more here: (http://akinainc.com/pdf/AI147%20HMMC-Acrylate%20crosslinking%20and%20micromoldin g.pdf).

-

BPCR conference (August 29, 2018 9AM - 4PM: Kurz Purdue Technology Center, West Lafayette, IN) is a free, 1-day scientific-networking conference hosted by Akina, Inc. See more BPCRconference.com

Outcomes