John Garner

Just in time for New Years: PLGA-NH2 from PolySciTech used in development of obesity treatment

Blog Post created by John Garner on Jan 2, 2019

Beije adipocyte polyscitech weight-loss.jpg

Around New Year’s, many people begin forming resolutions several of which involve losing weight. There are many causes and factors which contribute to weight gain and obesity. One of which is the disposition of metabolic energy derived from food, whether it is consumed in muscular contractions (exercise), used in biochemical functions (regular homeostasis maintenance), generation of heat or stored as fat. Recently, researchers at Purdue University published a patent describing the use of PLGA-NH2 (Polyyvivo AI010) from PolySciTech ( as part of nanoparticle therapy to encourage fatty cells to convert energy into heat rather than storing it as fat. This research holds promise to help in reduction of obesity and related cardiovascular and other diseases associated with this condition. Read more: Deng, Meng, Chunhui Jiang, Liangju Kuang, and Shihuan Kuang. "Polymer-based therapeutics for inductive browning of fat." U.S. Patent Application 15/771,312, filed November 15, 2018.


“Abstract: This disclosure features the methods and compositions involving development of novel polymer-based therapeutics that induce browning of white adipocytes for the treatment of obesity and its associated metabolic diseases. The therapeutic effects are largely attributed to the promotion of brown and/or beige adipocyte development and function by leveraging adipocyte plasticity and polymer-based drug delivery systems. Both brown and beige adipocytes are densely packed with mitochondria which highly express uncoupling protein-1 (UCP1), a thermogenic protein mediating non-shivering thermogenesis.”