John Garner

PolySciTech polymers used in recent patent regarding a new manufacturing technique to generate nanoparticles

Blog Post created by John Garner on Feb 7, 2019

wu, 2019 phosphorex patent.jpg

There are many different methods to generate nanoparticles and there are continuously new methods developed in this field. A recent patent by Phosphorex describes many PolySciTech (www.polyscitech.com) polymers for use in making nanoparticles including AV017 (mPEG-PLA-FKR648), AV18 (mPEG-PLGA-FKR560), AV016 (PLA-Fluorescein), AV013 (PLA-FPR648), AV015 (PLGA-FKR648), AV001 (PLGA-Fluorescein), AV006 (PLGA-FPI749), and AV011 (PLGA-Rhodamine B), AI016 (PLGA-NH2), AI025 (PLGA-SH), AI096 (PLGA-NHS), AI052 (PLGA-PEG-Mal), AI078 (PLGA-PEG-COOH), AI087 (PCL-NH2), AI021 (NH2-PLGA-NH2), AI086 (mPEG-PLGA-NH2). This research holds promise for further development of nanoparticle based technology. Read more: Wu, Bin. "Extremely small nanoparticles of degradable polymers." U.S. Patent Application 15/897,371, filed January 24, 2019. https://patents.google.com/patent/US20190021999A1/en

 

“Summary: The invention described herein is partly based on the realization that, to encapsulate a water-soluble drug, a double emulsion process is commonly used, which requires the polymer (e.g., PLGA polymer) to be dissolved in a water immiscible solvent, whereas the solvents used in the precipitation method are generally water miscible. Thus, to solve this problem, the current invention provides a method of synthesizing small polymeric nanoparticles by utilizing a single emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles by utilizing a double emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles loaded with therapeutic agents by utilizing a single emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles loaded with therapeutic agents by utilizing a double emulsion technique, described herein. This invention also provides a composition of small polymeric nanoparticles, described herein. This invention also provides a composition of small polymeric nanoparticles loaded with therapeutic agents, described herein. This invention also provides a composition of small polymeric nanoparticles coated with non-therapeutic agents, described herein.”

 

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