John Garner

PolySciTech PLGA-Rhodamine used in Research on Nanoparticle-based Cancer Therapy

Blog Post created by John Garner on Jun 18, 2019

One of the major drawbacks to conventional chemotherapy against cancer is that the drugs applied are often not specific to the cancer cells. Rather, they simply inhibit the growth of all cells (both tumor and healthy) which leads to severe side-effects of chemotherapy. One strategy to deal with this is to generate systems which direct the flow of the chemotherapeutic agents to the site of the tumor or into the cancer cells themselves. Recently, researchers at University of Minnesota used fluorescently-tagged PLGA-Rhodamine (AV011) from PolySciTech (www.polyscitech.com) to generate fluorescently traceable nanoparticles for MSC-mediated delivery to tumors. This research holds promise to improve the treatment of cancer. Read more: Layek, Buddhadev, Drishti Sehgal, Peter A. Argenta, Jayanth Panyam, and Swayam Prabha. "Nanoengineering of Mesenchymal Stem Cells via Surface Modification for Efficient Cancer Therapy." Advanced Therapeutics: 1900043. https://onlinelibrary.wiley.com/doi/pdf/10.1002/adtp.201900043

 

“Abstract: Mesenchymal stem cells (MSCs) can be used for tumor-specific delivery of small molecular weight anticancer drugs by using nanoparticle-encapsulated forms of the drugs. Current approaches to incorporate nanoparticles in MSCs rely on nonspecific endocytosis of nanoparticles or their conjugation to the cell surface via endogenous amines and thiols. These methods result in sub-optimal drug loading, which hinders the widespread application of MSCs as drug carriers. An advanced nanoengineering strategy is reported here that involves generation of MSCs expressing azide functional groups on their surface and conjugation of dibenzyl cyclooctyne-functionalized nanoparticles to the azide groups using copper-free click chemistry. This novel strategy significantly improves the payload capacity of MSCs (48 pg of paclitaxel (PTX) per cell) relative to that reported previously (<1–20 pg per cell), without affecting their native phenotype. In vivo, the nanoengineered MSCs significantly inhibit tumor growth (p < 0.05) and improve survival (p < 0.0001) compared to free or nanoparticle encapsulated PTX and Abraxane in an orthotopic ovarian tumor model. In summary, the nanoengineering strategy reported here allows for improved delivery and anticancer efficacy of conventional chemotherapeutic agents using MSCs as drug carriers.”

 

Biotech, Pharma, Cancer, Research (BPCR) is a free, 1-day scientific networking conference hosted by Akina, Inc. on Aug 28, 2019. See more and register to attend at www.bpcrconference.com

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