John Garner

PLGA-PEG-Mal from PolySciTech used in development of nanoparticle-based Parkinson’s disease treatment

Blog Post created by John Garner on Jul 16, 2019

Parkinson’s disease is an incurable progressive neurodegenerative disorder in which neural cells within the brain begin to break down and die. Notably, this affects cells which produce dopamine leading to severe chemical imbalances within the brain that create many of the symptoms of Parkinson’s disease. Treating Parkinson’s disease suffers from difficulty in getting the medicinal molecules to cross over the blood-brain-barrier. Recently, researchers at Yantai University, and Shandong Luye Pharmaceutical Co. (China) used Mal-PEG-PLGA (AI109) and mPEG-PLGA (AK104) from PolySciTech (www.polyscitech.com) to generate surface-modified nanoparticles designed to cross the blood-brain barrier. These particles were used as part of a dopamine delivery system. This research  holds promise to provide for improved Parkinson’s disease therapies in the future. Read more: Tang, Shengnan, Aiping Wang, Xiuju Yan, Liuxiang Chu, Xiucheng Yang, Yina Song, Kaoxiang Sun et al. "Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease." Drug delivery 26, no. 1 (2019): 700-707. https://www.tandfonline.com/doi/abs/10.1080/10717544.2019.1636420

 

“Abstract: Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that AUC0–12 h in the rat brain for dopamine Lf-BNPs was significantly higher (p < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson’s disease. Keywords: Dopamine, lactoferrin, borneol, nose-to-brain targeted nanoparticles, Parkinson’s disease”

 

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