John Garner

PLGA-PEG polymers from PolySciTech used in development of collagen-binding nanoparticles to prevent post-surgical adhesion

Blog Post created by John Garner on Sep 24, 2019

After a surgery, it is common for adhesions to form as the healing tissues will sometime heal to one another forming connections which are not meant to be there. These surgical adhesions create painful issues which can lead to side effects and complications. Recently, researchers at University of North Carolina at Chapel Hill, Duke University, and Jilin University (China) used mPEG-PLGA (AK029), Mal-PEG-PLGA (AI110), and PLGA-PEG-COOH (AI034) from PolySciTech (www.polyscitech.com) to create nanoparticles to prevent post-surgical adhesion. This research holds promise to prevent a common surgical complication. Read more: Mi, Yu, Feifei Yang, Cameron Bloomquist, Youli Xia, Bo Sun, Yanfei Qi, Kyle Wagner, Stephanie A. Montgomery, Tian Zhang, and Andrew Z. Wang. "Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion." Advanced Science (2019): 1900809. https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.201900809

 

“Abstract: Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo-crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials.”

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