John Garner

PLGA from PolySciTech used in development of antibiotic-releasing films from sinus stent

Blog Post created by John Garner on Jan 2, 2020

Chronic sinus infection can occur from antibiotic-resistant forms of pseudomonas bacteria. One means to hold the sinus open is to place a stent however further healing can be accomplished by having a drug-eluting layer on the stent release medicines into the surrounding tissue. Recently, researchers at The University of Alabama at Birmingham utilized PLGA from PolySciTech (www.polyscitech.com) as part of their development of a drug-eluting sinus stent. This research holds promise to improve therapies against antibiotic-resistant strains of bacteria that can lead to sinus issues. Read more: Lim, Dong‐Jin, Justin McCormick, Daniel Skinner, Shaoyan Zhang, Jeffrey B. Elder, John G. McLemore, Mark Allen et al. "Controlled delivery of ciprofloxacin and ivacaftor via sinus stent in a preclinical model of Pseudomonas sinusitis." In International Forum of Allergy & Rhinology. John Wiley & Sons, Ltd, 2019. https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22514

 

“Abstract: Background: Pseudomonas aeruginosa is common in chronic rhinosinusitus (CRS) and frequently resistant to antibiotic treatment. We recently described the ciprofloxacin and ivacaftor‒releasing biodegradable sinus stent (CISS)―a drug‐delivery system that administers ciprofloxacin and the mucociliary activator (ivacaftor) at high local concentrations with prolonged mucosal contact time and sustained delivery. The objective of this study is to evaluate the efficacy of the CISS in a rabbit model of P aeruginosa (PAO1 strain) sinusitis. Methods: Ciprofloxacin/ivacaftor (double layer) was coated on biodegradable poly‐D/L‐lactic acid (PLLA). A total of 10 sinus stents (5 bare PLLA stent controls, 5 CISSs) were placed unilaterally in rabbit maxillary sinuses via dorsal sinusotomy after inducing infection for 1 week with PAO1. Animals were assessed 3 weeks after stent insertion with sinus culture, nasal endoscopy, computed tomography scan, histopathology, and in‐vivo sinus potential difference (SPD) assay. Results: Rabbits treated with CISS had significant reductions in computed tomography (∆ Kerschner scale: control, 0.55 ± 0.92; CISS, −5.92 ± 1.69; p = 0.024) and endoscopy (control, 4.0 ± 0.0; CISS, 1.875 ± 0.74; p = 0.003) scores. A 2‐log reduction of PAO1 was observed (control, −2.14 ± 0.77; CISS, 1.84 ± 1.52; p = 0.047). SPD revealed significantly increased Cl− transport in the CISS group compared with the control group (Cl−‐free + forskolin ΔPD: control, −4.23 ± 1.04 mV; CISS, −18.36 ± 6.31 mV; p = 0.026). Finally, marked improvements were noted in the histology of the mucosa and submucosa in treated animals. Conclusion: The CISS had robust clinical efficacy in treating P aeruginosa rabbit sinusitis. The innovative design of double‐layered drug coating on the surface of the biodegradable stent may provide therapeutic advantages over current treatment strategies for P aeruginosa sinusitis.”

 

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