John Garner

PLGA from PolySciTech used in development of novel tissue adhesive formulation

Blog Post created by John Garner on Jan 2, 2020

During surgery and for healing of traumatic injuries it is often necessary to use bioadhesives to close wounds and hold tissues together. Such adhesives must have good adhesion to wet tissue (underlying skin, muscle, fat, etc.) as well as good biocompatibility/biodegradation to allow for subsequent healing of the joined tissues. Recently, researchers at The Pennsylvania State University, Harvard Medical School, (USA) Harbin Engineering University, Chengdu University, Southern Medical University, and Jilin Medical University (China) used PLGA (PolyVivo AP154) from PolySciTech (www.polyscitech.com) as a control article in their development of a citrate-based adhesive. This research holds promise to lead to improvements in tissue adhesives for surgical and regenerative medicine applications. Read more: Lu, Xili, Sanjun Shi, Hanmei Li, Ethan Gerhard, Zhihui Lu, Xinyu Tan, Wenliang Li et al. "Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives." Biomaterials (2019): 119719. https://www.sciencedirect.com/science/article/pii/S0142961219308373

 

“Abstract: Tissue adhesives are commonly used in surgeries and regenerative engineering for the repair and regeneration of topical and internal wounds on tissues and organs such as skin, heart, blood vessels, and bone. However, achieving rapid crosslinking, strong wet adhesion and cohesion strengths, and minimal cytotoxicity remains a critical roadblock for clinical translation. Herein, in contrast to harsh and cytotoxic oxidants, magnesium oxide (MgO) particles were found to facilitate rapid crosslinking for injectable citrate-based mussel-inspired tissue bioadhesives synthesized by reacting citric acid, PEG-PPG-PEG diol and dopamine (iC-EPE). Our results confirmed the role of MgO particles as both crosslinkers and composite fillers to concurrently enhance bioadhesive cohesion and adhesion. iC-EPE crosslinked by MgO with/without sodium periodate (PI) exhibit enhanced mechanical strengths (1.0 Mpa < tensile strength ≤ 4.5 MPa) compared to that of iC-EPE crosslinked only by PI (~0.75 MPa), high adhesion strength (up to 125 kPa, 8 fold that of fibrin glue (~15 kPa)), tunable degradability (full degradation from <1 week to > 1 month), excellent in vitro and in vivo biocompatibility, encouraging anti-bacterial performance, and favorable wound closure efficacy. Thus, MgO crosslinked bioadhesives possess great potential for a wide range of applications in surgery and regenerative engineering. Keywords: Magnesium oxide (MgO), Mussel-inspired adhesion, Citrate, Tissue adhesives, Wound closure”

 

 --> Save-the-date: Akina, Inc's third annual Biotech-Pharma-Cancer-Research (BPCR) conference is August 26 at Kurz Purdue Technology Center (KPTC) (http://bpcrconference.com/).

Outcomes