Leo Liu

Anisotropic Lignin Nanoparticles, A Potential Weapon Against Covid-19?

Blog Post created by Leo Liu on Mar 26, 2020

Lignin, the second abundant renewable resources next to cellulose, is part of our dietary fibers and has been shown to have human health benefits. Lignin has also confirmed to have antivirus properties and been patented against HIV (US 4,935,239). In addition, nanoparticles are known to exert their antiviral activities.

 

We are seeking here any qualified labs or institutions in the world to evaluate the anisotropic lignin nanoparticles invented by Solenis LLC (US Patent 10,035,928) as a potential agent against the coronavirus, Covid-19, to meet the urgent need for a cure.  The nanoparticles are formed in water via self-assembly of softwood Kraft lignin or solvent-extracted grass-lignin by a simple and convenient process, easy to scale up.  Nature creates lignin with cellulose of glucose polymer together, and this bonding power of lignin with glucose could be extended to lignin's interaction with the surface glycosylated spike-protein and/or membrane glucoprotein of Covid-19.  On the other hand, the soap-like property of the anisotropic particle could disrupt the lipid shell. US patent 4,935,239 already demonstrated that  high molecular weight lignin had high anti-viral activity, which also implied nanoparticles of extremely high killing capability.  If we can confirm they work to kill Covid-19 efficiently, we can immediately use the lignin nanoparticles as a safe and long lasting disinfectant on surfaces including human skin as a preventive measure first, so we can gain our time to develop the nanomaterial as a cure for the virus.

 

Demonstrated here is the surface-active property of the lignin nanoparticles created by the Solenis process.

The video (https://www.youtube.com/watch?v=Vo-T1WNZkk8&feature=youtu.be) shows the surface dynamics of lignin nanoparticles. They can be seen to turn hydrophobic surfaces (water beads up) into long lasting hydrophilic ones (water-sheeting), indicating the surface active properties.

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