Name:
Stephane Jean De Lombaert
Country:
USA
City:
Chester
State/Province:
CT
ACS Member:
Member
Local Section:
L102,Connecticut Valley
International Chapter:
Technical Division Membership:
Technical Division Membership Emeritus:
Subdivision Member:
ACS Activities:
Company/Institution Name:
Career Stage:
Professional
Research and Special Interests:
19 Years in drug discovery, including 13 years of integrated scientific & managerial experience in the pharmaceutical research industry --- Extensive background in medicinal chemistry, modern organic synthesis, & small molecule lead identification & optimization --- Multidisciplinary project management & leadership across several therapeutic areas (CV, CNS, metabolic disorders); various chronic disease indications (HT, CHF, athero, renoprotection, depression/stress disorders, obesity, pain); distinct biological target types (enzymes, GPCRs, ion channels); several external research collaborations (Pfizer, Aventis); first-in-class & best-in-class program types; small & large group sizes (3-26 medicinal chemists, BS to PhD levels); small (Neurogen) & larger (Novartis, Boehringer Ingelheim) pharmaceutical company research environment --- Project team leadership experience:
1. ACE/NEP inhibitors (1991-1993)
2. ECE inhibitors (1993-1997)
3. NPY receptor antagonists (1997-2000)
4. CRF-1 receptor antagonists (1997-1999)
5. VR1 antagonists (2000-2003)
6. sEH inhibitors (2003-2006)
7. CV project (2007- present) ---
Track record of scientific publications (>41); distinct patents on new composition of matter (>38); internal or collaborative research milestone achievements (>7 preclinical candidates) ---
Scientific management experience also includes development of groups & departments; contribution to & implementation of strategic initiatives; proposal & initiation of new research projects; coordination of external research collaborations; presentations/updates on project results/milestones, strategies & timelines; identification, recruiting, & retaining of top talents; performance evaluations/improvements & feedback; ensuring close and constant dialog between project teams & management through effective communication & presentation skills; presentation & evaluation of in-licensing opportunities
Area of Expertise:
Medicinal chemistry (lead identification and optimization),
Multidisciplinary project leadership/management/mentoring,
Modern organic synthesis,
Structure- and ligand-based design, peptidomimetics
Years of Expertise:
16-20