Publication Details (including relevant citation information):
Sunnapu, Ranganayakulu, Banoth, Saikumar Naik, R. S., Reyno, Thomas, Aleena, Venugopal, Navyasree, Rajendar, Goreti The Journal of Organic Chemistry 2020 85 (6) 4103-4113
Abstract: The first stereoselective total synthesis of (−)-(2S,4R)-3′-methoxy citreochlorol and (−)-(2S,4S)-3′-methoxy citreochlorol is demonstrated. A proline-based imidazolidinone was synthesized and used as chiral auxiliary for asymmetric acetate aldol reaction to generate initial chirality in the targeted molecule. Geminal dichloromethane functionality was introduced by the addition of in situ generated dichloromethyllithium to Weinreb’s amide functional group.
Address (URL): https://doi.org/10.1021/acs.joc.9b03227
