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New Contributor

Will the Dehydration of 4-Hydroxyphenylacetone with H2SO4 afford Phenylacetone?

Hello

Is it possible to eliminate the Para Hydroxy Group from 4-Hydroxyphenylacetone(CAS.770-39-8) with H2SO4 to afford Phenylacetone?

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New Contributor II

Re: Will the Dehydration of 4-Hydroxyphenylacetone with H2SO4 afford Phenylacetone?

I'd expect a lot of side reactions (aldol especially).

Also, the target compound is illegal in the US--I don't know where you're operating though. 😉

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New Contributor

Re: Will the Dehydration of 4-Hydroxyphenylacetone with H2SO4 afford Phenylacetone?

So maybe a selective dehydration would be the solution? Im currently in a Country where this Compound is not illegal, just for clarification!

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