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How to Conduct Drug-Excipient Compatibility Studies in Formulation Development?

In the dosage form, the API is in direct contact with other components (excipients) in the formulation, thus facilitating drug administration and release and protecting it from environmental impacts. Although excipients are pharmacologically inert, they can interact with drugs in dosage forms, thereby affecting the stability of drugs in physical aspects, such as sensory properties, reduced dissolution or Chemically, which can cause drug degradation. The effective formulation requires careful selection of excipients to make it easy to administer, improve patient compliance, promote drug release and bioavailability, and extend its shelf life. Therefore, the compatibility screening of API with excipients or other active ingredients, namely, API-excipient compatibility, is considered as one of the essential parts in preformulation.

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