MicroRNAs comprise a novel class of endogenous, small (only about 20 to 25 nucleotides), and noncoding RNAs, and almost involved in the physiologic and pathologic process of cardiovascular system. MicroRNAs, in common, play the similar roles as transcription factors by specifically binding the seed sequence within 3’UTR of target genes, by activating their degradation or inhibiting their translation of the target genes mRNAs or inhibit their translation, which result in variety of cell activities changing at different levels.
