hERG Inhibition assays (screens or GLP-compliant, pre-IND assays) offer extraordinary sensitivity, much greater than whole-organ assays, or whole-animal assays. Of course, proper study design and data interpretation decreases the risk of false positives resulting from this immense sensitivity. It is therefore imperative, when considering hERG inhibition patch-clamp data, to obtain expert interpretation, usually from the study director who oversaw the study.
