Assays for cisplatin-DNA adducts

[suo_zucai]

Cisplatin is an anticancer drug. Can anyone tell me the best assays to identify and quantitate cisplatin modification of a short DNA oligomer? Thanks.

-Zucai Suo

[srikanthkotapati]

Please go through this article:

Development of an Ultraperformance Liquid Chromatography/Mass

Spectrometry Method To Quantify Cisplatin 1,2 Intrastrand

Guanine-Guanine Adducts

Chem. Res. Toxicol. 2009, 22, 905–912

Hope this answers your question

regards

Srikanth