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Application of Promestriene in the treatment of vaginal atrophy

Vaginal atrophy is a consequence of reduced estrogen in urogenital and pelvic tissue that results in a loss of vaginal elasticity, dryness, decreased lubrication, dyspareunia, and urinary symptoms. 

As a synthetic estrogen analog, promestriene has two important attributes.

  • Firstly, promestriene is very poorly absorbed from the **bleep** and does not affect systemic hormone levels or estrogen activity.
  • Secondly, promestriene has demonstrated anti-atrophic activity in the genitourinary tract, which leads to significant improvement in symptoms associated with vaginal atrophy.
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