Influencing Factors of Tablet Fragility
The purpose of the tablet fragility test is to determine the resistance of tablets against mechanical stress, both shaking and erosion. The higher the percentage of fragility, the greater the loss of tablet life, a good fragility value is < 1%.
- API: The physical and chemical properties and stability of API have a great influence on the friability of tablet.
- Excipients: such as adhesives, fillers.
- Production process: mixing time, granule dryness, compression pressure, etc. will affect the friability of the tablet.
