Pharmaceutical Chemists

Supplementation of tablet candy, a health food, it not only relieves fatigue, but also helps to improve the body's immunity, so that people who are prone to colds, slowly feel relaxed. In addition to the above-mentioned effects, it can also replenish the body's fluid and other substances, which can help the heart, liver, spleen, lungs, kidneys and other organs. It can also moisten the lungs, nourish the stomach and produce body fluid, strengthen the brain and brighten the eyes, so it is helpful to most people. ... View more

Cosmetics are chemically mixed substances made from natural, synthetic or extracted substances with different effects, processed through production procedures such as heating, stirring and emulsification.  There are three Main Propellant Chemicals Used in Cosmetics, namely, 2-Methylbutane (CAS 78-78-4), Dimethyl carbonate (CAS 616-38-6 ), Pentane (CAS 109-66-0). ... View more

Influencing Factors of Tablet Fragility The purpose of the tablet fragility test is to determine the resistance of tablets against mechanical stress, both shaking and erosion. The higher the percentage of fragility, the greater the loss of tablet life, a good fragility value is < 1%. API: The physical and chemical properties and stability of API have a great influence on the friability of tablet. Excipients: such as adhesives, fillers. Production process: mixing time, granule dryness, compression pressure, etc. will affect the friability of the tablet. ... View more

Methods for Moisture Content Determination Drying methods： Direct determination Absorption of water in a suitable drying agent (desiccant is measured before and after absorption) Indirect determination - mass loss of the sample Drying of the samples under precisely defined conditions -, methods in an oven method Exposing the sample to dry atmosphere (as in a desiccator) Routine methods： Method with NIR (Near Infrared Reflectance) analyzer Method with NIT (Near Infrared Transmission) analyzer ... View more

Solubility testing methods Saturation concentration measurement This method is used to measure the solubility by adding the drug to the medium until it starts to precipitate and the concentration of the drug in the excipient is no longer increasing. UPLC/HPLC technique When using liquid lipid excipients, UPLC/HPLC can be used to determine the equilibrium solubility of the drug. Differential thermal scanning calorimetry (DSC) & hot stage microscopy (HSM) techniques When semi-solid lipid excipients are used, differential scanning calorimetry (DSC) and/or hot bench microscopy (HSM) can be used for relevant measurements. Solubility curve method development Solubility curves are obtained by continuous dynamic method testing. Assay Method Validation In order to examine whether the analytical assay methods described above have excellent results for solubility and solubility curves, we performed method validation services. The method specificity, linearity, range, accuracy, repeatability and intermediate precision are evaluated to ensure the validity and reliability of the method. ... View more