Organic chemists face the ongoing challenge of developing and optimizing a synthesis for active pharmaceutical ingredients (APIs), namely, API synthesis. These challenges involve a multitude of issues designed to improve yield, purity, stereoselectivity, process conditions (i.e., temperature and pressure), scalability, and production economics. A recent literature review reveals insight into some of these challenges as they relate to organic chemical production overall and pharmaceutical chemical development in particular. See more at http://www.pharmtech.com/improving-api-synthesis
