Modern diagnostics in the realms of biomedical research and therapeutics depend heavily on molecular imaging. Synthetic peptides that target certain receptors have been developed as a result of the overexpression or expression of particular receptors by cancer cells. The use of peptides conjugated to metal chelates (such as DOTA, NOTA, etc.) as imaging agents for cancer tissues and as therapeutic agents that transport deadly payload to cancer cells is appealing.
2-supplementary metal ions:
One of the most crucial roles of peptides-metal chelates conjugation is to encourage metal ion absorption. Chelate iron has a higher bioavailability in living things than inorganic iron. The chelates in the form of carriers are the reason why iron ions at the core of the ring structure can move freely across the intestinal mucosa's brushing edge, facilitating iron absorption, transport, and utilisation.
3-As bacteriostatic or antioxidant agents
The antioxidation, antimicrobial, and other special biological activities of the chelates were higher than those of the unchelated peptides, or the chelates obtained some biological activities that were not present in unchelated peptides, after chelating peptides from various sources with metal ions. There is almost no safety issue because peptides, one of the building blocks of chelates, are derived from organic animal and plant proteins. As a result, chelates offer many benefits visit and promising futures in the food, cosmetics, and other industries as antioxidants or bacteriostatic agents.