1-Regarding molecular imaging:
Modern diagnostics in the realms of biomedical research and therapeutics depend heavily on molecular imaging. Synthetic peptides that target certain receptors have been developed as a result of the overexpression or expression of particular receptors by cancer cells. The use of peptides conjugated to metal chelates (such as DOTA, NOTA, etc.) as imaging agents for cancer tissues and as therapeutic agents that transport deadly payload to cancer cells is appealing.
2-supplementary metal ions:
One of the most crucial roles of peptides-metal chelates conjugation is to encourage metal ion absorption. Chelate iron has a higher bioavailability in living things than inorganic iron. The chelates in the form of carriers are the reason why iron ions at the core of the ring structure can move freely across the intestinal mucosa's brushing edge, facilitating iron absorption, transport, and utilisation.
3-As bacteriostatic or antioxidant agents
The antioxidation, antimicrobial, and other special biological activities of the chelates were higher than those of the unchelated peptides, or the chelates obtained some biological activities that were not present in unchelated peptides, after chelating peptides from various sources with metal ions. There is almost no safety issue because peptides, one of the building blocks of chelates, are derived from organic animal and plant proteins. As a result, chelates offer many benefits visit and promising futures in the food, cosmetics, and other industries as antioxidants or bacteriostatic agents.
Peptide-metal chelate conjugation has a wide range of applications in various fields such as medicine, biochemistry, and biotechnology. Some of the most common applications are:
Medical imaging: Peptide-metal chelate conjugates are used in diagnostic medical imaging, such as PET (Positron Emission Tomography) and SPECT (Single Photon Emission Computed Tomography) scans. The metal chelate acts as a tracer to locate specific biological targets in the body.
Cancer therapy: Peptide-metal chelate conjugates are also being studied for their potential use in cancer therapy. The metal chelate can be used to deliver toxic substances directly to cancer cells, while leaving healthy cells unharmed.
Drug delivery: Peptide-metal chelate conjugates can be used to deliver drugs to specific target sites in the body, improving drug efficacy and reducing side effects.
Protein purification: Metal chelate conjugates can be used in protein purification to selectively bind and isolate proteins of interest.
Biosensors: Peptide-metal chelate conjugates can be used as biosensors to detect specific biomolecules or pathogens in clinical or environmental samples.
Overall, peptide-metal chelate conjugation provides a versatile tool for targeted delivery and detection in various applications, making it an important area of research in many fields.
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Chelates play important roles in oxygen transport and in photosynthesis. Furthermore, many biological catalysts (enzymes) are chelates. In addition to their significance in living organisms, chelates are also economically important, both as products in themselves and as agents in the production of other chemicals.