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Richard Partch

kate1dc
Contributor II
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Partch_Richard.jpgProfessor Partch, currently Sr. University Professor, started his career as a synthetic medicinal/organic chemist focusing on sterically hindered porhyrins as hemoglobin mimics and steroid neurotransmitters. Influenced by colloid science he co-pioneered aerosol synthesis of inorganic and organic particles, and was among the first to apply organic chemistry to in situ surface modification of dispersed particles of many shapes, sizes and compositions for successful application to ceramic, composite, electronic, imaging, medicine and obscurant technologies. He has published over 70 original papers and holds several patents, and given invited/plenary presentations at international meetings. His popular 1-2 day Short Course on Particle Surface Modification has been offered at professional meetings and to industry. He is a frequent invited speaker on chemistry at high schools, State Science Teacher Conventions, and community service organizations.

Professor Partch was appointed a DuPont Teaching Fellow as a PhD student, is recipient as Assistant Professor of a National Academy of Science Research Fellowship and a Rotary Foundation Scholar Fellowship. At Clarkson he has received Outstanding Service Award, Distinguished Faculty Service Award, Computer Curriculum Development Award, and Distinguished Honors Faculty Award. He has for 40 years been active locally and nationally in ACS and Sigma Xi and has received the NNY ACS Section Distinguished Service Award and the Service Recognition Award by the Council of the ACS.

More information is available at www.clarkson.edu/CAMP and www.clarkson.edu/~partch

Topics

Sandpaper, Toothpaste, Computer Chips: What Do They Have In Common?

Periodically everything needs cleaning: bedrooms, offices, windows, floors, pictures, automobiles, eye lenses, stoves and teeth are but a few examples. Sometimes the dirt can be removed merely by passing a damp cloth over the surface. But other times pressure must be applied to the cloth, or an abrasive sponge is required. The key word that relates to the title question is “abrasive”. The most common and long used abrasive is sandpaper, which is a collection of irregular-shaped and purposely jagged particles glued to a paper backing. Today, burned food on glass tops on stoves is removed by using a pad composed of porous plastic. Toothpaste and some types of car paint polishing agents also contain abrasive particles but in much smaller size than even the smallest abrasives in finishing sandpaper. These smaller abrasives are now called nanoparticles, under 1 micron in dimension. The manufacture of computer chips starts with a copper wafer that looks like a CD but in larger diameter. Several layers of alternating electrically conducting and insulating chemicals are deposited on top of the copper but after each deposition the new chemical layer must be polished to be very smooth. The polishing is done using a plastic pad and a liquid slurry containing special nanoparticles capable of removing one type of surface more than another. This process is called “Chemical Mechanical Planarization. It was first created at IBM over 30 years ago and the technology has been greatly advanced by chemists and engineers worldwide. Clarkson University faculty have achieved in the field of particle technology in general and in CMP in particular. In this presentation the speaker will discuss the chemistry and mechanics of use of abrasives in several consumer products and in manufacture of computer chips.

Nanoparticles for Cancer and Chemical Overdose Therapies

An interdisciplinary approach to reducing lethal effects of overdoses of toxic chemicals in vivo is yielding new information on potential application of nanoparticle technology. Several thousand deaths occur each year due to exposure to excess prescription therapeutics such as local anesthetics and antidepressants, over-the-counter medicines like Tylenol and Ibuprofen, and even cocaine. Presented is experimental information on in-vivo remediation involving 1) oil-in-water microemulsions formulated from oil droplets stabilized by pluronic and caprylate co-surfactants; and 2) pi-pi complex properties of receptor aromatic rings attached to carrier nanoparticles which bind to some commonly overdosed therapeutics and street drugs, and possibly even to biotoxins like ricin. R. Partch, E. Powell, Y-H. Lee, M. Varshney, D. Shah, R. Baney, D-W. Lee, D. Dennis, T. Morey and J. Flint., Surface Modification of Dispersed Phases Designed for In Vivio Removal of Overdosed Toxins. In Finely Dispersed Particles, A. Spasic and J-P. Hsu, Eds, Ch. 28(2005) 813-832. All biological cells are sensitive to heat, hence hyperthermia is a process to be avoided. However, developments in nanoparticle compositions and understanding of their in vivo transport and biocompatibility properties has resulted in a new cancer treatment method called “Photo Thermal Therapy”. It involves injecting tiny functionalized gold particles into the blood stream which are injected into cancer cells in higher quantity than into normal cells, followed by exposing the cancerous region to infrared light. The radiation selectively heats the gold photon absorbers to a degree depending on particle concentration. Some experimental efforts are underway in the speaker’s laboratory to improve the technology and to employ a visible marker for seeing the particles as they flow and cluster in cells.

Aerosol and Liquid Dispersions for Particle Surface

There are many experimental methods for preparing free-flowing colloidal material. The terms “precipitation” and “sol-gel” are possibly the most well know of the reactions run in liquids, but gas phase processes have also been developed and are used in industry. The preparation of coated or so-called “core-shell” colloids usually takes place in two stages: core preparation followed by sequential or by separate surface treatments. Coatings can be continuous over the core or may be tethered molecules with portions of the core still exposed. The aerosol method of preparing both core and core-shell particles, of either or both inorganic and organic composition, was co- pioneered by the presenter and involves generating droplets of a reactive liquid followed by exposure to a gas-phase co-reactant. Droplet size precision and aerosol flow conditions can be selected to produce mono-disperse solids. Dispersions of colloids in a solvent containing a dissolved material are media in which by either chemical (polymerization) or physical (evaporation) methods core-shell particles or cores with tethered functionality are commonly prepared. Examples of chemicals, experimental methods and reaction conditions for generation of several types of colloids will be included in this presentation.

Contact


Clarkson University

8 Clarkson Ave.

Box 5814

Potsdamn, NY, United States, 13699

E-Mail: partch@clarkson.edu

Home: 315-265-7324

Business: 315-268-2351

Fax: 315-268-7615

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