This website uses cookies. By clicking Accept, you consent to the use of cookies. Click Here to learn more about how we use cookies.
Accept
Reject
Help

Upcoming Webinars

cancel
Turn on suggestions
Auto-suggest helps you quickly narrow down your search results by suggesting possible matches as you type.
Showing results for 
Search instead for 
Did you mean: 

Upcoming Webinars
Approaches to Uncooperative Drugs in In Vitro Transporter Research
Tuesday, October 3, 2023
Register.
In vitro drug transporter data is critical for understanding drug-drug interaction potential, but this data is only useful if conclusions can be drawn. Researchers are confronted with practical challenges associated with compounds that are unstable, sticky or insoluble, resulting in convoluted or inconclusive results.    Three interesting transporter case studies will be presented, each highlighting a creative solution to explore perplexing initial results and generate useful data, despite problematic physicochemical characteristics of the drugs involved.    Key Learning Objectives: Fundamental test system and platform limitations in drug transporter research  Practical methodologies to account for nonspecific binding and instability in transporter studies  Study designs with case studies  Who Should Attend: Research scientists and drug development leadership aiming for successful IND / NDA submission, needing to meet regulatory requests and expectations, desiring to formulate a development plan that mitigates risks of late-stage failure, or simply wanting to better understand the ADME properties and potential DDI risks of their compound. Brought to you by: Speakers: Joanna Barbara, PhD ADME Research Site Head, BioIVT Melissa O'Meara Forensic Science Consultant, C&EN Media Group
%7Bafd22d1b-40f1-40b7-9e2a-f1b7eddab301%7D_BioIVT-Drug-Transport-Resources
Labels (2)
Labels
Event has ended
Lab X-ray Absorption: A New Dimension for Materials Characterization
Wednesday, October 11, 2023
Register
X-ray Absorption Spectroscopy (XAS) is a powerful and versatile technique that fits into the larger landscape of material characterization techniques by providing unique, element-specific insights into the local atomic structure, electronic properties, and bonding interactions of materials. It complements and enhances the information obtained from other characterization methods, contributing to a more comprehensive understanding of materials.     In this session, we will discuss the utility of XAS and how newly developed lab-scale instrumentation enables its practical use as an everyday tool for materials characterization. Come see real world applications of laboratory XAS.    Key Learning Objectives: Introduction to X-ray Absorption Spectroscopy and its unique capabilities for materials characterization. Detailed look into example applications of laboratory XAS.  Overview of new lab-scale XAS instrumentation. Understanding the process of conducting a laboratory XAS measurement, including a real-time measurement demonstration.  Who Should Attend: Research Scientists from Universities or Industries that routinely perform materials characterization. Materials Characterization Lab Managers and Users interested in understanding new techniques. Those interested in element-specific, non-destructive material analysis. Brought to you by: Speakers: Dr. Devon Mortensen CEO, easyXAFS Dr. William Holden CTO, easyXAFS Dr. Zachary Lebens-Higgins Testing and R&D Manager, easyXAFS Catherine Dold Health & Environment Writer, C&EN Media Group
%7Bf5943144-ae31-4e7f-b5dd-2921be25a0a4%7D_C_EN_webinar_graphic
Labels (2)
Labels
Event has ended
Shining Light on AAVs: Using Light Scattering Technologies to Solve Challenges in Characterization
Wednesday, October 18, 2023
Register
With the rising clinical and commercial successes of AAV-based gene therapies, there is an ever-growing demand for robust, platform analytical technologies that can help ensure better product quality, safety, and efficacy. Size exclusion chromatography (SEC) and Field Flow Fractionation (FFF), coupled with multi-angle light scattering technologies (MALS), are rapidly emerging as transformative technologies for rapid and accurate characterization of AAV samples. Critical Quality Attributes (CQAs) such as capsid titer, genome titer, empty/full, % aggregation and purity of various AAV serotypes can all be obtained in a single measurement. This multi-attribute approach dramatically reduces operational costs and reduces drug development timelines.     Key Learning Objectives: See how SEC-MALS compares to orthogonal techniques (ddPCR, Capsid ELISA’s, and AUC) for the characterization of AAV during various downstream steps   Understand how light scattering can be used as a rapid screening tool when working with multiple AAV serotypes  Appreciate the value of FFF-MALS for accurate, AAV aggregation analysis   Who Should Attend: Academic researchers involved in biophysical studies  Academic researchers involved in gene therapy studies  Gene Therapy - Discovery  Gene Therapy - Development Gene Therapy – QC Government researchers involved in gene therapy research Brought to you by:   Speakers: Steven Milian, M.S. Sr. Staff Scientist, Research & Development Dept. of Patheon (by Thermo Fisher Scientific) Viral Vector Services Gennarino Del Bagno, B.S. Lead Scientist, Research & Development Dept. of Patheon (by Thermo Fisher Scientific) Viral Vector Services Melissa O'Meara Forensic Science Consultant, C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
Event has ended
Direct Analysis of Glycosylated Therapeutics
Thursday, October 19, 2023
Register
Glycosylation plays a crucial role in determining the pharmacological properties of biotherapeutics. The molecular heterogeneity of glycosylated biotherapeutics makes it difficult to provide thorough characterization of intact glycoproteins by mass spectrometry. Current methods for analyzing biotherapeutics only measure fragments of the compound or rely on partial digestion of the glycans to reduce sample complexity. These limitations pose important risks and challenges for biotechnology companies that need to report human-compatible and consistent glycosylation, critical for drug safety and efficacy.     We will present a new approach to glycoform fingerprinting that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact glycoproteins by mass spectrometry. The method provides a detailed landscape of the intact molecular weights present in biotherapeutic protein preparations in a single experiment and offers insights into glycoform composition when coupled with a suitable bioinformatic strategy. In addition, we highlight the application of charge detection native mass spectrometry (Direct Mass Technology mode) towards the elucidation of masses and aggregation of heterogeneous glycosylated biotherapeutics.    Key Learning Objectives: How to elucidate masses from heterogeneous glycosylated biotheraputics  Learn how proton transfer charge reduction (PTCR) can simplify complex protein mixtures  Learn when to use PTCR based methods compared to Direct Mass Technology mode for analysis of biotherapeutics  Who Should Attend: Laboratory Managers  Biopharmaceutical Researchers  Protein Scientists  Brought to you by: Speakers: Wendy Sandoval Director, Translational Mass Spectrometry, Genentech Ann Thayer Contributing Editor, C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
Event has ended
Empowering Small Molecule Drug Discovery by Automatic DEL Screening
Thursday, October 26, 2023
Register
DNA-encoded library (DEL) technology has proven to be a powerful tool for drug discovery. There are now several DEL-derived candidates in clinical stage. DEL enables researchers to explore vast chemical space with millions to billions of compounds with low cost, limited time and minimal effort.     Scientists in both industry and academics are both trying to further expand the utility of DEL. WuXi AppTec has been practicing DELopen collaborations with many university researchers with free DEL kits. This has significantly spread the DEL compounds into many drug discovery labs and accelerated the research process. WuXi AppTec has also been providing DEL kit services for our industrial partners to help them implement DEL as one of the benchtop drug discovery tools.    However, to fully promote DEL screening ideas to the next level, it would not be sufficient to just distribute DEL compounds into the lab. The standardization of the screening procedure is paramount. Given that a DEL screen needs several rounds of experiments to enrich the compounds, it is vital to lower the contamination and human error in operation to a negligible level for a qualified screen.    WuXi AppTec has profound DEL screening experience on a wide spectrum of proteins. With the combination of the automatic system, WuXi AppTec has released the first automatic DEL screening device - DELman. With DELman and other self-service data analysis tools, researchers can easily wield DEL screens in appointed scenarios and obtain stable and reliable screening outcomes.    Key Learning Objectives: The self-service DEL tools for global researchers  New features of the automatic DEL screen device  Special edition of DEL kit   Who Should Attend: Academics interested in screening their (protein/biomolecule) targets for drug-like chemical matter in a flexible collaboration mode Industry scientists interested in conducting DEL screens Brought to you by: Speakers: Wenji Su, PhD Executive Director, Head of Early Discovery Platform, WuXi Biology Weiren Cui, PhD Director, Head of Hit Finding and Informatics Department, Early Discovery Platform, WuXi Biology Chang Liu, PhD Associate Director, Early Discovery Platform, WuXi Biology Catherine Dold Health & Environment Writer, C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
Event has ended
Mastering UPW Quality with Real-Time Trace Ion Detection
Tuesday, October 31, 2023
Register
Ultrapure water (UPW) is crucial for the production of superior-quality semiconductors, but ensuring final product quality can be a challenge without the right tools. UPW undergoes extensive and costly purification, utilizing various physical and chemical treatments to meet increasingly rigorous purity standards. In the face of global water shortages, efficient UPW production is essential. Water recycling facilities at semiconductor plants are tasked with addressing this concern, regenerating wastewater back into UPW. However, the integrity of regenerated UPW must be verified to ensure final product quality. This is where online ion chromatography provides a novel advantage: detecting trace anions, cations, and silica contaminants in real-time down to parts-per-trillion levels.     Join us for a conversation with two industry experts: Ben Greenwood, Senior Manager at Micron Technology's Chemistry Lab, and Dariana Martinez, Product Application Specialist at Metrohm USA. Together, they will delve into the pressing water challenges currently faced by the semiconductor industry. Additionally, they will shed light on the pivotal role of ultrapure water and the significance of real-time ion chromatography to ensure quality control.     Key Learning Objectives: Understand the pivotal role of ultrapure water (UPW) in semiconductor manufacturing and its direct impact on product quality and performance.  Gain insights into the scale of water consumption in the semiconductor industry and the pressing challenges faced in meeting increasingly rigorous purity standards.  Discuss the advanced analytical capabilities of online ion chromatography, and learn how it accurately measures anions, cations, and silica contaminants to verify UPW purity.  Who Should Attend: Anyone interested in leveraging automation for process optimization and near-real-time data analytics Process engineers and plant operators responsible for analytical testing and QA/QC Managers responsible for ensuring maximum product quality Those involved in adopting or implementing Industry 4.0 initiatives and/or focused on developing newer, more efficient manufacturing processes Brought to you by:  Speakers: Ben Greenwood Senior Manager Micron Technology's Chemistry Lab Dariana Martinez Product Application Specialist Metrohm USA Melissa O'Meara Forensic Science Consultant C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
Event has ended
How to Optimize Formulation & Measurement with a Unified Laboratory Informatics Solution
Thursday, November 9, 2023
Register
Managing large amounts of data stored and shared across various applications and tools has been and continues to be challenging for Materials, Chemicals, and broader R&D teams worldwide. With so much complexity in formulation, measurement, testing, and analysis, legacy data systems and incumbent solutions limit effective data management, leading to errors and inefficient decision-making. Today, new, and cutting-edge structured data systems and unified laboratory informatics platforms are redefining Materials and Chemical Development organizations and driving better decisions and innovation.    In this webinar, we'll discuss the limitations of legacy data systems and the benefits of implementing a modern, unified solution. Discover how a structured data system can help streamline workflows, improve collaboration, and provide accurate, accessible data for better decision-making and innovation. Learn the differences between ELNs, LIMS, and modern structured data systems. Don't miss this opportunity to take your development to the next level.    Key Learning Objectives: What is a Unified Laboratory Informatics Platform?  Best practices for frictionless change management when digitalizing your lab How to assess the right digital lab solution for your R&D organization How to define a roadmap for seamless LIMS, ELN, and unified data management system deployment How to enable end-to-end formulation & measurement data capture The importance of structured lab data for critical business decision-making Who Should Attend: Research & Development Leaders Innovation & Technology Leaders Product Development Leaders interested in streamlining data management R&D Leaders interested in digital transformation Enterprise R&D Leaders in the advanced materials, chemicals, food & beverage, cosmetics, pharma & biotech, process & chemical, and/or oil & gas industries Brought to you by: Speakers: Jason Hirshman CTO and Co-Founder, Uncountable Kelly McSweeney Contributing Editor, C&EN Media Group
%7Bd143cc47-e904-4045-828d-6b8e6eaf6993%7D_C_EN___UNC_Webinar_Banner
Labels (2)
Labels
Event has ended
No Compromises, Native Molecule Drug Discovery Assays Using Mass Spectrometry
Thursday, November 30, 2023
Register
Recently there has been increased interest in screening chemical libraries for non-covalent or covalent binding to RNA or protein drug discovery targets using native conditions. Solution phase binding with native targets and test compounds avoids potential compromises inherent to assays based on labeled or immobilized components. In this webinar, we will describe simple, automated, and high throughput workflows utilizing mass spectrometry (MS) to measure drug candidate binding. Two workflows will be described in detail: 1) non-covalent/reversible binding by Affinity Selection Mass Spectrometry (ASMS) and 2) covalent/irreversible binding by intact mass shift assays.    Both methodologies facilitate the efficient interrogation of large data sets in a high-throughput manner followed by further hit candidate characterization. These MS-based assay methods are applicable to many different classes of targets and therapeutic areas, for example: RNA and protein degraders, RNA as a novel drug target, molecular glues and protein-protein interactions. Some of the advantages of this methodology over other drug target binding assay methods are minimal target quantity and assay development is required, protocol flexibility, target versatility, and primary hits are immediately identified and available for further confirmation and follow-up experiments (i.e., K inact /K i  measurements, peptide mapping, quantitative proteomics, etc.).    Key Learning Objectives: Understand how and when to use the ASMS & intact mass shift workflows for drug discovery screening Learn about the advantages of native molecule mass spectrometry binding assays versus other methodologies Learn how to utilize mass spectrometry for hit follow-up confirmation and characterization Who Should Attend: Scientists interested in drug discovery screening, especially binding assays Pharma/Biopharma VPs, Directors, and team leaders looking to improve the success rate and speed to results of their drug discovery binding assays Brought to you by: Speakers: Can Ozbal Founder & CEO, Momentum Biotechnologies William LaMarr Senior VP Research & Development, Momentum Biotechnologies Melissa O'Meara Forensic Science Consultant, C&EN Media Group
%7Bbc882b6f-b3db-4e58-be91-38d2fce0cb89%7D_Shopper-ASMS_Row_squat
Labels (2)
Labels
​​In-Line and On-Line Monitoring of CQAs for Biologics, Vaccines and Gene Vectors
Tuesday, December 5, 2023
Register
​Biologics, vaccines, and gene therapies are emerging as novel pharmaceutical modalities. These products contain complex macromolecules such as proteins, polysaccharides, lipid nanoparticles, and viral vectors. Biophysical attributes of these molecules, such as molar mass, particle size, and particle concentration, inform product critical quality attributes (CQAs).    Light-scattering analysis following downstream operations, such as chromatographic purification and polishing, can rapidly provide CQAs, enabling process control and quality monitoring in real time. This webcast will review the principles, capabilities and limitations of real-time multi-angle light scattering (RT-MALS), and then present case studies covering downstream processing of viral vectors, proteins, polysaccharides and lipid nanoparticles.   Key Learning Objectives: The capabilities of multi-angle light scattering for in-process, real-time analytics  ​​How RT-MALS integrates with various downstream unit operations to provide deep process knowledge and rapid process optimization  The benefits of timely feedback on relevant product attributes and CQAs for controlling the recovery and purification of biologics and gene vectors Who Should Attend: Downstream process development scientists who wish to accelerate process development PAT SMEs looking for in-line and on-line analytical technologies to monitor biopharmaceutical product attributes, control downstream processing, optimize yield and maintain quality Brought to you by:   Speakers: Dan Some ​Principal Scientist​, Wyatt Technology​ Alexandra Taylor Contributing Editor, C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
Mastering Tricks for Improving Chromatography in Difficult Samples
Wednesday, December 6, 2023
Register
Ion chromatography, a crucial method for separating and quantifying ionic components, faces complexities in diverse sample matrices. To meet stringent analysis standards and ensure IC component longevity, sample pretreatment is essential. Samples with elevated particulate loads, extreme pH, colloids or high cation concentrations jeopardize chromatographic integrity, potentially reducing column lifespan. Considerations extend to IC-incompatible matrices, like those involving organic solvents, and scenarios requiring ultra trace analyses with preconcentration.    While manual methods exist, the revolutionary shift to inline automation for sample preparation promises increased efficiency, throughput, prolonged column lifespan and notable enhancements in data accuracy and reproducibility. Join our upcoming webinar for an insightful exploration led by Sylvia Singh, Ion Chromatography Applications Specialist at Metrohm USA, who will unravel the intricacies and significant benefits of inline sample preparation for analytical processes.    Key Learning Objectives: Learn about the benefits of inline sample preparation for ion chromatography Discover the types Metrohm inline sample preparation that are available Gain an understanding of applications that benefit from inline automation Learn how to choose the best inline sample prep technique for your sample type and laboratory need Who Should Attend: Analysts, technicians, chemists who are either currently using or plan to use IC  Lab managers considering automation for their current IC  Students and researchers who may use IC  Brought to you by:   Speakers: Dr. Sylvia Singh Applications Specialist for Ion Chromatography Metrohm USA Melissa O'Meara Forensic Science Consultant C&EN Media Group
ACS Webinars Hub Placeholder Image.png
Labels (2)
Labels
View:

From Food Chemistry to Career Advice to the latest on COVID-19 Vaccines, ACS Members with the Premium Package have exclusive access to the entire library of ACS Webinars® recordings.

Explore the Library

Stay up to date with the latest scientific research, applications and technology. Recordings of C&EN Webinars are available to the general public for 1 year after broadcast.

Explore the Library