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Upcoming Webinars

X-ray Absorption Spectroscopy (XAS) is a powerful and versatile technique that fits into the larger landscape of material characterization techniques by providing unique, element-specific insights into the local atomic structure, electronic properties, and bonding interactions of materials. It complements and enhances the information obtained from other characterization methods, contributing to a more comprehensive understanding of materials.     In this session, we will discuss the utility of XAS and how newly developed lab-scale instrumentation enables its practical use as an everyday tool for materials characterization. Come see real world applications of laboratory XAS.    Key Learning Objectives: Introduction to X-ray Absorption Spectroscopy and its unique capabilities for materials characterization. Detailed look into example applications of laboratory XAS.  Overview of new lab-scale XAS instrumentation. Understanding the process of conducting a laboratory XAS measurement, including a real-time measurement demonstration.  Who Should Attend: Research Scientists from Universities or Industries that routinely perform materials characterization. Materials Characterization Lab Managers and Users interested in understanding new techniques. Those interested in element-specific, non-destructive material analysis. Brought to you by: Speakers: Dr. Devon Mortensen CEO, easyXAFS Dr. William Holden CTO, easyXAFS Dr. Zachary Lebens-Higgins Testing and R&D Manager, easyXAFS Catherine Dold Health & Environment Writer, C&EN Media Group
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With the rising clinical and commercial successes of AAV-based gene therapies, there is an ever-growing demand for robust, platform analytical technologies that can help ensure better product quality, safety, and efficacy. Size exclusion chromatography (SEC) and Field Flow Fractionation (FFF), coupled with multi-angle light scattering technologies (MALS), are rapidly emerging as transformative technologies for rapid and accurate characterization of AAV samples. Critical Quality Attributes (CQAs) such as capsid titer, genome titer, empty/full, % aggregation and purity of various AAV serotypes can all be obtained in a single measurement. This multi-attribute approach dramatically reduces operational costs and reduces drug development timelines.     Key Learning Objectives: See how SEC-MALS compares to orthogonal techniques (ddPCR, Capsid ELISA’s, and AUC) for the characterization of AAV during various downstream steps   Understand how light scattering can be used as a rapid screening tool when working with multiple AAV serotypes  Appreciate the value of FFF-MALS for accurate, AAV aggregation analysis   Who Should Attend: Academic researchers involved in biophysical studies  Academic researchers involved in gene therapy studies  Gene Therapy - Discovery  Gene Therapy - Development Gene Therapy – QC Government researchers involved in gene therapy research Brought to you by:   Speakers: Steven Milian, M.S. Sr. Staff Scientist, Research & Development Dept. of Patheon (by Thermo Fisher Scientific) Viral Vector Services Gennarino Del Bagno, B.S. Lead Scientist, Research & Development Dept. of Patheon (by Thermo Fisher Scientific) Viral Vector Services Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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Thursday, October 19, 2023
Glycosylation plays a crucial role in determining the pharmacological properties of biotherapeutics. The molecular heterogeneity of glycosylated biotherapeutics makes it difficult to provide thorough characterization of intact glycoproteins by mass spectrometry. Current methods for analyzing biotherapeutics only measure fragments of the compound or rely on partial digestion of the glycans to reduce sample complexity. These limitations pose important risks and challenges for biotechnology companies that need to report human-compatible and consistent glycosylation, critical for drug safety and efficacy.     We will present a new approach to glycoform fingerprinting that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact glycoproteins by mass spectrometry. The method provides a detailed landscape of the intact molecular weights present in biotherapeutic protein preparations in a single experiment and offers insights into glycoform composition when coupled with a suitable bioinformatic strategy. In addition, we highlight the application of charge detection native mass spectrometry (Direct Mass Technology mode) towards the elucidation of masses and aggregation of heterogeneous glycosylated biotherapeutics.    Key Learning Objectives: How to elucidate masses from heterogeneous glycosylated biotheraputics  Learn how proton transfer charge reduction (PTCR) can simplify complex protein mixtures  Learn when to use PTCR based methods compared to Direct Mass Technology mode for analysis of biotherapeutics  Who Should Attend: Laboratory Managers  Biopharmaceutical Researchers  Protein Scientists  Brought to you by: Speakers: Wendy Sandoval Director, Translational Mass Spectrometry, Genentech Ann Thayer Contributing Editor, C&EN Media Group
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DNA-encoded library (DEL) technology has proven to be a powerful tool for drug discovery. There are now several DEL-derived candidates in clinical stage. DEL enables researchers to explore vast chemical space with millions to billions of compounds with low cost, limited time and minimal effort.     Scientists in both industry and academics are both trying to further expand the utility of DEL. WuXi AppTec has been practicing DELopen collaborations with many university researchers with free DEL kits. This has significantly spread the DEL compounds into many drug discovery labs and accelerated the research process. WuXi AppTec has also been providing DEL kit services for our industrial partners to help them implement DEL as one of the benchtop drug discovery tools.    However, to fully promote DEL screening ideas to the next level, it would not be sufficient to just distribute DEL compounds into the lab. The standardization of the screening procedure is paramount. Given that a DEL screen needs several rounds of experiments to enrich the compounds, it is vital to lower the contamination and human error in operation to a negligible level for a qualified screen.    WuXi AppTec has profound DEL screening experience on a wide spectrum of proteins. With the combination of the automatic system, WuXi AppTec has released the first automatic DEL screening device - DELman. With DELman and other self-service data analysis tools, researchers can easily wield DEL screens in appointed scenarios and obtain stable and reliable screening outcomes.    Key Learning Objectives: The self-service DEL tools for global researchers  New features of the automatic DEL screen device  Special edition of DEL kit   Who Should Attend: Academics interested in screening their (protein/biomolecule) targets for drug-like chemical matter in a flexible collaboration mode Industry scientists interested in conducting DEL screens Brought to you by: Speakers: Wenji Su, PhD Executive Director, Head of Early Discovery Platform, WuXi Biology Weiren Cui, PhD Director, Head of Hit Finding and Informatics Department, Early Discovery Platform, WuXi Biology Chang Liu, PhD Associate Director, Early Discovery Platform, WuXi Biology Catherine Dold Health & Environment Writer, C&EN Media Group
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Ultrapure water (UPW) is crucial for the production of superior-quality semiconductors, but ensuring final product quality can be a challenge without the right tools. UPW undergoes extensive and costly purification, utilizing various physical and chemical treatments to meet increasingly rigorous purity standards. In the face of global water shortages, efficient UPW production is essential. Water recycling facilities at semiconductor plants are tasked with addressing this concern, regenerating wastewater back into UPW. However, the integrity of regenerated UPW must be verified to ensure final product quality. This is where online ion chromatography provides a novel advantage: detecting trace anions, cations, and silica contaminants in real-time down to parts-per-trillion levels.     Join us for a conversation with two industry experts: Ben Greenwood, Senior Manager at Micron Technology's Chemistry Lab, and Dariana Martinez, Product Application Specialist at Metrohm USA. Together, they will delve into the pressing water challenges currently faced by the semiconductor industry. Additionally, they will shed light on the pivotal role of ultrapure water and the significance of real-time ion chromatography to ensure quality control.     Key Learning Objectives: Understand the pivotal role of ultrapure water (UPW) in semiconductor manufacturing and its direct impact on product quality and performance.  Gain insights into the scale of water consumption in the semiconductor industry and the pressing challenges faced in meeting increasingly rigorous purity standards.  Discuss the advanced analytical capabilities of online ion chromatography, and learn how it accurately measures anions, cations, and silica contaminants to verify UPW purity.  Who Should Attend: Anyone interested in leveraging automation for process optimization and near-real-time data analytics Process engineers and plant operators responsible for analytical testing and QA/QC Managers responsible for ensuring maximum product quality Those involved in adopting or implementing Industry 4.0 initiatives and/or focused on developing newer, more efficient manufacturing processes Brought to you by:  Speakers: Ben Greenwood Senior Manager Micron Technology's Chemistry Lab Dariana Martinez Product Application Specialist Metrohm USA Melissa O'Meara Forensic Science Consultant C&EN Media Group
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Managing large amounts of data stored and shared across various applications and tools has been and continues to be challenging for Materials, Chemicals, and broader R&D teams worldwide. With so much complexity in formulation, measurement, testing, and analysis, legacy data systems and incumbent solutions limit effective data management, leading to errors and inefficient decision-making. Today, new, and cutting-edge structured data systems and unified laboratory informatics platforms are redefining Materials and Chemical Development organizations and driving better decisions and innovation.    In this webinar, we'll discuss the limitations of legacy data systems and the benefits of implementing a modern, unified solution. Discover how a structured data system can help streamline workflows, improve collaboration, and provide accurate, accessible data for better decision-making and innovation. Learn the differences between ELNs, LIMS, and modern structured data systems. Don't miss this opportunity to take your development to the next level.    Key Learning Objectives: What is a Unified Laboratory Informatics Platform?  Best practices for frictionless change management when digitalizing your lab How to assess the right digital lab solution for your R&D organization How to define a roadmap for seamless LIMS, ELN, and unified data management system deployment How to enable end-to-end formulation & measurement data capture The importance of structured lab data for critical business decision-making Who Should Attend: Research & Development Leaders Innovation & Technology Leaders Product Development Leaders interested in streamlining data management R&D Leaders interested in digital transformation Enterprise R&D Leaders in the advanced materials, chemicals, food & beverage, cosmetics, pharma & biotech, process & chemical, and/or oil & gas industries Brought to you by: Speakers: Jason Hirshman CTO and Co-Founder, Uncountable Kelly McSweeney Contributing Editor, C&EN Media Group
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Recently there has been increased interest in screening chemical libraries for non-covalent or covalent binding to RNA or protein drug discovery targets using native conditions. Solution phase binding with native targets and test compounds avoids potential compromises inherent to assays based on labeled or immobilized components. In this webinar, we will describe simple, automated, and high throughput workflows utilizing mass spectrometry (MS) to measure drug candidate binding. Two workflows will be described in detail: 1) non-covalent/reversible binding by Affinity Selection Mass Spectrometry (ASMS) and 2) covalent/irreversible binding by intact mass shift assays.    Both methodologies facilitate the efficient interrogation of large data sets in a high-throughput manner followed by further hit candidate characterization. These MS-based assay methods are applicable to many different classes of targets and therapeutic areas, for example: RNA and protein degraders, RNA as a novel drug target, molecular glues and protein-protein interactions. Some of the advantages of this methodology over other drug target binding assay methods are minimal target quantity and assay development is required, protocol flexibility, target versatility, and primary hits are immediately identified and available for further confirmation and follow-up experiments (i.e., K inact /K i  measurements, peptide mapping, quantitative proteomics, etc.).    Key Learning Objectives: Understand how and when to use the ASMS & intact mass shift workflows for drug discovery screening Learn about the advantages of native molecule mass spectrometry binding assays versus other methodologies Learn how to utilize mass spectrometry for hit follow-up confirmation and characterization Who Should Attend: Scientists interested in drug discovery screening, especially binding assays Pharma/Biopharma VPs, Directors, and team leaders looking to improve the success rate and speed to results of their drug discovery binding assays Brought to you by: Speakers: Can Ozbal Founder & CEO, Momentum Biotechnologies William LaMarr Senior VP Research & Development, Momentum Biotechnologies Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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​Biologics, vaccines, and gene therapies are emerging as novel pharmaceutical modalities. These products contain complex macromolecules such as proteins, polysaccharides, lipid nanoparticles, and viral vectors. Biophysical attributes of these molecules, such as molar mass, particle size, and particle concentration, inform product critical quality attributes (CQAs).    Light-scattering analysis following downstream operations, such as chromatographic purification and polishing, can rapidly provide CQAs, enabling process control and quality monitoring in real time. This webcast will review the principles, capabilities and limitations of real-time multi-angle light scattering (RT-MALS), and then present case studies covering downstream processing of viral vectors, proteins, polysaccharides and lipid nanoparticles.   Key Learning Objectives: The capabilities of multi-angle light scattering for in-process, real-time analytics  ​​How RT-MALS integrates with various downstream unit operations to provide deep process knowledge and rapid process optimization  The benefits of timely feedback on relevant product attributes and CQAs for controlling the recovery and purification of biologics and gene vectors Who Should Attend: Downstream process development scientists who wish to accelerate process development PAT SMEs looking for in-line and on-line analytical technologies to monitor biopharmaceutical product attributes, control downstream processing, optimize yield and maintain quality Brought to you by:   Speakers: Dan Some ​Principal Scientist​, Wyatt Technology​ Alexandra Taylor Contributing Editor, C&EN Media Group
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Ion chromatography, a crucial method for separating and quantifying ionic components, faces complexities in diverse sample matrices. To meet stringent analysis standards and ensure IC component longevity, sample pretreatment is essential. Samples with elevated particulate loads, extreme pH, colloids or high cation concentrations jeopardize chromatographic integrity, potentially reducing column lifespan. Considerations extend to IC-incompatible matrices, like those involving organic solvents, and scenarios requiring ultra trace analyses with preconcentration.    While manual methods exist, the revolutionary shift to inline automation for sample preparation promises increased efficiency, throughput, prolonged column lifespan and notable enhancements in data accuracy and reproducibility. Join our upcoming webinar for an insightful exploration led by Sylvia Singh, Ion Chromatography Applications Specialist at Metrohm USA, who will unravel the intricacies and significant benefits of inline sample preparation for analytical processes.    Key Learning Objectives: Learn about the benefits of inline sample preparation for ion chromatography Discover the types Metrohm inline sample preparation that are available Gain an understanding of applications that benefit from inline automation Learn how to choose the best inline sample prep technique for your sample type and laboratory need Who Should Attend: Analysts, technicians, chemists who are either currently using or plan to use IC  Lab managers considering automation for their current IC  Students and researchers who may use IC  Brought to you by:   Speakers: Dr. Sylvia Singh Applications Specialist for Ion Chromatography Metrohm USA Melissa O'Meara Forensic Science Consultant C&EN Media Group
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Traditional UV/Vis spectroscopy uses fixed pathlengths to measure different analytes, such as nucleic acids, proteins, and cells from biological samples. These samples are often limited in volume or highly concentrated, which presents various challenges.     The CTech™ SoloVPE® System uses patented variable pathlength technology (VPT) to accurately measure the targeted concentration of various analytes in less than 2 minutes. The system can measure concentrations without being dependent on sample volume or sample concentration, removing any dilution requirements.    In this webinar, we will review VPT and how it can be used in various applications from protein to nucleic acid therapeutics. We will share real-world case studies demonstrating how companies have integrated the SoloVPE System into their manufacturing workflow for release and in-process testing.     Key Learning Objectives: The science of variable pathlength spectroscopy and why variable pathlength provides better accuracy than traditional fixed pathlength methods Overview of the SoloVPE System and the benefits:   No sample dilutions Guaranteed linear results  No baseline correction Testing of low and very high concentration samples from 0.01 mg/mL up to 300mg/mL (MAbs)  Implementing in the analytics/QC lab or in the production suite for at-line testing (IPT)   Review SoloVPE implementation in multiple applications - quantitate proteins, nucleic acids and excipient analysis, such as polysorbate and free sulfhydryl concentrations Who Should Attend: Process Development Scientist  Analytical Development Scientist   Quality Control, Quality Assurance Scientist Manufacturing Science and Technology (MSAT) Scientist  Brought to you by: Speakers: Joe Ferraiolo Director, Bioanalytics Applications, Repligen Catherine Dold Health & Environment Writer, C&EN Media Group
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The progress in RNA-based therapies has seen significant advancements, including the approval of pioneering treatments like patisiran in 2018 and the recent development of COVID-19 vaccines using Lipid nanoparticle (LNP) formulations. Researchers have optimized the effectiveness of these therapies by leveraging electrostatic complexation of anionic RNA, utilizing a composition of cationic and ionizable lipids, combined with other lipids. High-throughput screening using robotic automation in a 96-well plate format has emerged as an efficient method, demonstrating results comparable to the current state-of-the-art methods.    To automate the LNP formulation for screening purposes, a protocol was established using the Andrew+ liquid handling platform. The method was developed to overcome challenges such as rapid evaporation of ethanolic lipid solutions. The automated method maintained consistent particle size and high mRNA encapsulation efficiency. The transfection efficiency into HepG2 cells was comparable to both manual pipetting and microfluidics based LNP preparation methods. Thus, the automated method using Andrew+ has shown promise in streamlining LNP formulation and advancing the development of mRNA-based therapies, offering high precision and repeatability for the high-throughput screening of various LNPs.    Key Learning Objectives: Preparation of mRNA loaded LNPs  Comparison of manual pipetting, automated pipetting using Andrew+ and microfluidic methods  LNP characterization and high-throughput in vitro screening  Who Should Attend: Researchers, industry laboratory heads and technicians in the field of LNP formulation or pipetting automation  Students new to the field of LNP formulation  Brought to you by: Speakers: Dr. Ryan Karongo Scientific Labhead, Drug Targeting and Vectors Team, Bayer AG Dr. Michael Karimov Research Scientist, Drug Targeting and Vectors Department, Bayer AG Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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Tuesday, March 5, 2024
Join Asst. Prof Caitlin Davis of Yale University to learn about recent research on a critical metabolic process in live cells – de novo lipogenesis, using a breakthrough new technology that enables IR spectroscopy and imaging at submicron spatial resolution on a wide range of samples including in water. The breakthrough technology that enables sub-micron IR spectroscopy is Optical Photothermal IR Spectroscopy (O-PTIR). Prof. Davis will discuss how she uses O-PTIR to probe metabolic heterogeneity in live cells with rapid sub-micron IR imaging.     In the opening part of this webinar, hear from Dr. Mustafa Kansiz (PSC), as he provides an introductory overview of O-PTIR and how it’s being used by scientists in a wide range of application areas including, life science, microplastics, pharmaceutical sub-visible particulates and contamination identification in industrial failure analysis.  Key Learning Objectives: Understand the principle of operation for submicron IR spectroscopy  Learn about specific applications of simultaneous IR and Raman  How O-PTIR can advance your research goals and increase the impact of your publications  Who Should Attend: Research Professors and Academics  Laboratory Directors and Managers   Industrial Failure Analysis Engineers Chemical and Polymer Engineers and Scientists Vibrational Spectroscopists  Brought to you by: Speakers: Prof Caitlin Davis Assistant Professor of Chemistry, Yale University       Dr. Mustafa Kansiz Director of Product Management, Photothermal Spectroscopy Corp     Alexandra Taylor Contributing Editor, C&EN Media Group  
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Wednesday, March 6, 2024
To remain competitive against other technologies, mass spectrometry (MS) needs to rise to the challenge of unprecedented throughput with very deep analyses of very complex samples. With analysis time reduced to several minutes by fast liquid separations, confident identification and quantitation over many orders of dynamic range still requires a generational leap in the sequencing performance of MS. The Thermo Scientific™ Astral™ analyzer is a novel class of high-resolution accurate-mass analyzer that compliments the Thermo Scientific™ Orbitrap™ analyzer to provide high speed and sensitivity measurements.   This webinar will explore the underlying technology of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer and its’ application to biomedical research. Rethink what is possible with a mass spectrometer including the analysis of 300 proteomics samples per day, measuring 5,000 proteins from a true single-cell, and collecting fragmentation data on over 90% of compounds in metabolomics experiments.   Key Learning Objectives: Learn about the novel technology of the Orbitrap Astral mass spectrometer   Understand the benefits of the Orbitrap Astral mass spectrometer   How to apply the Orbitrap Astral mass spectrometer to solve biological questions  Who Should Attend: Academic Researchers  R&D Scientists  Lab Technicians Principal Investigators Lab Managers  Brought to you by: Speakers: Dr. Alexander Makarov Director, Global Research LSMS, Thermo Fisher Scientific Dr. Hamish Stewart Staff Scientist, Analytical Instruments Group, Thermo Fisher Scientific Ann Thayer Contributing Editor, C&EN Media Group
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Wednesday, March 27, 2024
With a new generation of cloud HPC and AI tools, computational chemistry and materials science is scaling and accelerating R&D efforts that could address some of our world’s toughest challenges. While there are few concrete examples of computational discoveries that have been validated experimentally, a shift is finally starting to take place.    In this special session, Microsoft will share some of its latest updates, including how a collaboration with Pacific Northwest National Laboratory is demonstrating methods to accelerate scientific discovery for energy storage solutions. Together, the teams have been able to discover and synthesize a material that shows potential for resource-efficient batteries in less than nine months. We will explore how advancements in HPC and AI are accelerating the next frontier of scientific breakthroughs, in turn compressing the next 250 years of chemistry into the next 25.    Key Learning Objectives: Learn how cloud-based high-performance computing and artificial intelligence can scale and accelerate discovery in materials science.  Explore one of Microsoft’s latest computational discoveries that was accelerated using Azure Quantum Elements.  Find out how Microsoft collaborated with Pacific Northwest National Laboratory to discover and synthesize a material to advance sustainable energy-storage solutions.  Discover how industry innovators adopted Azure Quantum Elements to transform their research and development.  Who Should Attend: Computational Materials Scientists  R&D Leaders  Computational Chemists  Digitization Managers C-suite  Brought to you by: Speakers: Dr. Nathan Baker Azure Quantum Elements Product Leader, Microsoft Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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A new wave of drugs that achieve the targeted delivery of radioisotopes are rapidly gaining momentum and attracting significant excitement. As the discovery and development pipeline widens, and new drug approvals increase, the field is expanding and becoming more diverse in the strategies employed to deliver the cell-killing radioisotopes.   One area that is showing considerable promise is the incorporation of an isotope-chelating moiety into a peptide ligand for a cell surface receptor on the cancer cells of interest. In this webinar we will discuss strategies for the discovery and optimisation of new peptide ligands for such targets, as well as their synthesis, investigation of efficacy, metabolism and distribution, and ultimately their manufacture.   Key Learning Objectives:   Understand the latest developments in peptide radiopharmaceuticals Learn how new peptide leads can be identified for this modality See how the latest imaging technologies can help identify and characterize new diagnostic and therapeutic molecules Who Should Attend:   Academic and industry scientists involved in radiopharmaceutical discovery, optimization, characterization and development. All levels from laboratory scientists to business leaders in this modality area.   Brought to you by: Speakers:     Jiazhi Liu, Associate Director, WuXi AppTec     Shaowei Wang, Assistant Director, Molecular Imaging Center, WuXi AppTec     Alex Satz, Executive Director, Head of Hits Europe, WuXi AppTec     Dave Madge, VP, Discovery Services, WuXi AppTec     Ann Thayer Contributing Editor, C&EN Media Group  
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In this webinar, Uncountable, a unified laboratory informatics software provider, and their customer, Beiersdorf, a global leader in skincare innovation, team up to discuss their partnership in digitally transforming R&D processes in the cosmetics industry.    This session will examine how Beiersdorf leverages Uncountable's platform to complement its digital R&D capabilities. It will focus on three objectives: streamlining global collaboration, enabling knowledge sharing and efficiency across multiple product lines, and enhancing more sustainable product development practices.    This webinar will provide valuable insights for R&D leaders looking to streamline data management, empower global collaboration, and foster more sustainable product development. Don't miss this opportunity to see how Beiersdorf and Uncountable are setting new benchmarks in the industry. Key Learning Objectives:   Gain insights from Beiersdorf’s experts on the current and future landscape of R&D within the cosmetics industry Learn how Uncountable collaborated with Beiersdorf to support their transformation toward more sustainable product development Discover today’s best practices and the importance of capturing data and insights across your organization while also protecting and securing your valuable datasets and IP Find out how to foster global teamwork and transition from siloed data sets to a fully digital laboratory ecosystem Explore how Uncountable’s platform’s predictive AI/ML DoE tool enables greater sustainability and efficiency across Beiersdorf’s R&D efforts   Who Should Attend:   Enterprise Research & Development Leaders (CTO, VP of R&D, Director of R&D for enterprise companies) Product Development Industry Leaders representing personal care, cosmetics, CPG, and other adjacent industries Enterprise R&D Leaders interested in digital transformation, improving sustainability, streamlining data management, and accelerating their research to commercialization efforts. R&D leaders interested in improving sustainability efforts   Brought to you by: Speakers:     Will Tashman CRO & Co-Founder Uncountable     Thomas Schornstein Lab Manager and Co-Lead of Future Lab Beiersdorf     Yanel de Moral Lab Manager and Co-Lead of Future Lab Beiersdorf     Melissa O'Meara Contributing Editor, C&EN Media Group    
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Antibody-drug conjugates (ADCs) are a novel modality leveraging monoclonal antibody (mAb)-mediated delivery of a cytotoxic payload molecule to its target. Since the drug conjugated to mAb, typically a highly cytotoxic small molecule, can be released unconjugated in plasma and contribute to drug-drug interaction (DDI) potential, both the antibody and small molecule drug component are considered from the perspective of ADC safety.   Numerous chemotherapies utilizing ADCs are being developed for treatment of advanced cancers, however, the regulatory guidance for evaluation of ADC DDI potential is not well established.   Key Learning Objectives:   Introduce the novel therapeutic modality of antibody-drug conjugates Summarize the mechanism of action and safety considerations for FDA-approved ADCs Describe drug interaction potential of ADC payloads currently in the clinic Outline experimental strategies for identification of drug interaction potential for novel small molecule ADC payloads   Who Should Attend:   Research scientists and drug development leadership aiming for successful IND / NDA submission, needing to meet regulatory requests and expectations, desiring to formulate a development plan that mitigates risks of late-stage failure, or simply wanting to better understand the ADME properties and potential DDI risks of their ADC.   Brought to you by: Speakers:     Maciej Czerwinski, PhD Director of Consulting BioIVT     Catherine Dold Health & Environment Writer, C&EN Media Group        
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  Vaccines based on mRNA technology demonstrated notable success during the COVID-19 pandemic. A crucial aspect of their efficacy lies in a formulation using lipid nanoparticles, enabling mRNA to enter the cell interior and initiate spike protein synthesis in the ribosomes. This formulation typically comprises four components, with particular emphasis on two: ionizable lipids and PEG lipids. To meet the demands of a large patient population during the pandemic, substantial quantities of lipids were required for vaccine production, necessitating a rapid scale-up of manufacturing processes.   This webinar will explore the specific requirements for industrializing processes in the production of ionizable lipids and PEG lipids, elucidating concepts to address typical challenges. Frequent restrictions include high molecular weight, the oily nature of pure substances, and the often absent chromophore. Both purification and analytics present unique challenges that must be carefully considered during synthesis.     Key Learning Objectives: Understand the essential requirements for scaling up processes and producing key lipids for Nano Particles. Identify specific challenges in lipid production and develop effective strategies to overcome them. Gain insights into the analytical aspects of lipid process research and development (R&D) and scale-up.   Who Should Attend: Researchers with focus on process scale-up Chemists and other scientists from Academia interested in recent developments in the pharmaceutical industry Lab technicians   Brought to you by:   Speakers: Joerg Jung Sr. Director Small Molecule Development Curia Global     Melissa O'Meara Forensic Science Consultant, C&EN Media Group  
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Modern titration offers a simple, yet highly accurate method to ensure the quality and safety of many products we consume daily. While not a complicated technique, there are some subtleties that can ensure your titration results are accurate. Simple electrode care and optimization of basic titration parameters are crucial to helping you obtain results you can trust.   During this webinar, Sagar Irrinki, Quality Control Manager at Coastal Gulf & International, Inc. will share how his laboratory navigates executing these tests on various types of titration applications. and how to overcome challenges with helpful titration tips. Eduardo Simoes, Product Specialist for Titration at Metrohm USA, will provide guidance for electrode selection and best practices for electrode care and maintenance. Don’t miss the live Q&A at the end to get all your questions answered by Sagar and Eduardo.    Key Learning Objectives:   Understand potentiometric electrode care and maintenance  Learn how to overcome titration challenges with useful tips Receive simple guidelines to remove doubt from titration results  Learn how to select the appropriate electrode for your titration   Who Should Attend:   Anyone who wants to learn more about electrode care and maintenance People interested in improving the consistency of their titration results Anyone who needs a refresher on titration best practices Chemists who want simple tips to improve confidence in titration analysis   Brought to you by: Speakers:     Eduardo Simoes Titration Product Specialist Metrohm USA     Sagar Irrinki Quality Control Manager Coastal Gulf & International, Inc.     Alexandra Taylor Contributing Editor C&EN Media Group      
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