Alex Dean

CCR and Diseases

Discussion created by Alex Dean on Apr 25, 2019

CCR is used as coreceptor in the early stage of infection. Coreceptor CCR is the first target of HIV-1 infection. Different types of CCR antagonists have different blocking mechanisms. However, although coreceptor antagonists can effectively prevent HIV-1 infection and curb the prevalence of AIDS, the development of these inhibitors is also facing challenges. Long-term use of an inhibitor will eventually lead to resistance to HIV-1. Therefore, the development of more drug-resistant anti-HIV drugs, and the combination of drugs will be the main direction in the future treatment of AIDS.