CCR is used as coreceptor in the early stage of infection. Coreceptor CCR is the first target of HIV-1 infection. Different types of CCR antagonists have different blocking mechanisms. However, although coreceptor antagonists can effectively prevent HIV-1 infection and curb the prevalence of AIDS, the development of these inhibitors is also facing challenges. Long-term use of an inhibitor will eventually lead to resistance to HIV-1. Therefore, the development of more drug-resistant anti-HIV drugs, and the combination of drugs will be the main direction in the future treatment of AIDS.